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SLC45A3 Antibody

  • 中文名称：
    SLC45A3兔多克隆抗体
  • 货号：
    CSB-PA211673
  • 规格：
    ￥1100
  • 图片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: CSB-PA211673(SLC45A3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q96JT2
  • 基因名：
    SLC45A3
  • 别名：
    IPCA 2 antibody; IPCA 8 antibody; IPCA6 antibody; PCANAP2 antibody; PCANAP6 antibody; PCANAP8 antibody; Prostate cancer associated gene 2 antibody; Prostate cancer associated gene 6 antibody; Prostate cancer associated gene 8 antibody; Prostate cancer associated protein 2 antibody; Prostate cancer associated protein 6 antibody; Prostate cancer associated protein 8 antibody; Prostate cancer-associated protein 6 antibody; Prostein antibody; PRST antibody; S45A3_HUMAN antibody; Slc45a3 antibody; Solute carrier family 45 member 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human SLC45A3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Identification of a novel autoimmune peptide epitope of prostein in prostate cancer has been reported. PMID: 27700103
    2. CTCF has a role in regulating SLC45A3-ELK4 Chimeric RNA PMID: 26938874
    3. genome-wide association studies show that the top SNP associated with log PSA 9Prostate-specific antigen) levels was rs2153904 in SLC45A3. PMID: 25434496
    4. Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population. PMID: 23269536
    5. This study provides first evidence that the expression of SLC45A3 protein is down regulated through SLC45A3-ERG fusion in prostate cancer. PMID: 22821757
    6. Data suggest that chimeric SLC45A3-ELK4 controls prostate cancer cell proliferation, and the chimera level correlates with prostate cancer disease progression. PMID: 22719019
    7. Double sequential immunohistochemical staining with p63 and P501S is highly specific and can be a useful tool in distinguishing urothelial carcinoma from prostate carcinoma. PMID: 21777423
    8. This is the first study to report concurrent TMPRSS2 and SLC45A3 rearrangements in the same tumor focus in prostate cancer PMID: 20118910
    9. T cells that recognize naturally processed epitopes from prostein were expanded from healthy donors and characterized. T cells isolated from males were of low avidity and recognized subdominant epitopes while those from females were of higher avidity PMID: 15048720
    10. Prostein is expressed in the vast majority of prostatic tissues, regardless of grade and metastatic status. No expression was detected in 4,700 normal and malignant tissue samples representing the great majority of essential tissues and tumors. PMID: 15176054
    11. P501S is a sensitive and highly specific marker for identifying prostate tissue. Combined use of prostein/prostate specific antigen used to detect prostatic origin of metastatic carcinomas. PMID: 17721190
    12. A SLC45A3:ETV5 gene fusion was identified in prostate cancer. PMID: 18172298
    13. Intronic miRNAs from tissue-specific transcripts, or their natural absence, make cardinal contributions to cellular gene expression and phenotype. PMID: 18193184
    14. This study demonstrates that most ERG-overexpressing prostate cancers harbor hormonally regulated TMPRSS2-ERG, SLC45A3-ERG, or NDRG1-ERG fusions PMID: 19649210
    15. SLC45A3-ELK4 may represent the first description of a recurrent RNA chimaeric transcript specific to prostate cancer that does not have a detectable DNA aberration PMID: 19136943

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family
  • 组织特异性：
    Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.
  • 数据库链接：

    HGNC: 8642

    OMIM: 605097

    KEGG: hsa:85414

    STRING: 9606.ENSP00000356113

    UniGene: Hs.278695