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SLIT3 Antibody

  • 货号：
    CSB-PA270713
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA270713(SLIT3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA270713(SLIT3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O75094
  • 基因名：
    SLIT3
  • 别名：
    FLJ10764 antibody; KIAA0814 antibody; MEGF 5 antibody; MEGF5 antibody; Multiple EGF-like domains protein 5 antibody; Multiple epidermal growth factor like domains 5 antibody; Multiple epidermal growth factor-like domains protein 5 antibody; SLIL 2 antibody; SLIL2 antibody; SLIT 1 antibody; Slit 2 antibody; Slit 3 antibody; Slit homolog 3 (Drosophila) antibody; Slit homolog 3 antibody; Slit homolog 3 protein antibody; Slit-3 antibody; SLIT1 antibody; Slit2 antibody; Slit3 antibody; SLIT3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human SLIT3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
  • 基因功能参考文献：
    1. Overexpression of Slit3 induces its tumor suppressive effects in Breast cancer. PMID: 26542734
    2. Results show that silencing of Slit3 promoted proliferation, migration and invasion of A549 cells and induced epithelial-mesenchymal transition suggesting that Slit3 functions as a tumor suppressor in lung carcinoma. PMID: 26045181
    3. Estrogen-dependent expression of SLIT3 may play a key role in regulating nerve-vessel interactions within the complex microenvironment of endometriosis lesions. PMID: 25051436
    4. SLIT3 is increased with labour, and both amnion and myometrial studies describe a pro-inflammatory effect of SLIT3 in these tissues. PMID: 24286238
    5. High SLIT3 expression is associated with high-grade gliomas. PMID: 24158112
    6. SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. PMID: 24090675
    7. results implicate the involvement of miR-218-2 and its host gene SLIT3 in thyroid cancer cell invasion, migration, and proliferation PMID: 23720784
    8. Slit3 treatment increased the in vivo homing efficiency of CD34 HSPCs to the BM in NOD/SCID mice, whereas Slit3-exposed HSPC migration in vitro was inhibited. Results support a role for Slit3 in human HSPC migration in vitro and homing in vivo. PMID: 22614124
    9. SLIT3 duplication on 5q35.1 predisposes to major depressive disorder PMID: 21152026
    10. The chemorepellent Slit3 promotes monocyte migration. PMID: 21078908
    11. Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. PMID: 20298552
    12. Many variants in SLIT3 tend to associate with schizophrenia susceptibility in the Chinese Han population. PMID: 15231749
    13. data suggest that Slit proteins play a key role in guiding dorsally projecting cranial motoneurons and in facilitating their neural tube exit PMID: 16162649
    14. In fetal and embryonic stem cell cultures Slit-3 inhibited neurite outgrowth. PMID: 16840550
    15. functions to promote angiogenesis in coordinating organogenesis during embryonic development PMID: 19741192

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Predominantly expressed in thyroid.
  • 数据库链接：

    HGNC: 11087

    OMIM: 603745

    KEGG: hsa:6586

    STRING: 9606.ENSP00000430333

    UniGene: Hs.552087