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ST3GAL2 Antibody

  • 货号：
    CSB-PA022752GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q16842
  • 基因名：
    ST3GAL2
  • 别名：
    3-GalNAc-alpha-2 antibody; 3-sialyltransferase 2 antibody; 3-sialyltransferase antibody; 3-ST 2 antibody; Alpha 2 antibody; Alpha 2,3-ST antibody; Beta-galactoside alpha-2 antibody; Beta-galactoside alpha-2,3-sialyltransferase antibody; CMP N-acetylneuraminate beta galactosamide alpha 2,3 sialyltransferase antibody; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2 antibody; Gal NAc6S antibody; Gal-beta-1 antibody; Gal-NAc6S antibody; SIA4B_HUMAN antibody; sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase) antibody; Sialyltransferase 4B antibody; SIAT4-B antibody; SIAT4B antibody; ST3 beta-galactoside alpha-2,3-sialyltransferase 2 antibody; ST3Gal II antibody; ST3GAL2 antibody; ST3GalA.2 antibody; ST3GalII antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ST3GAL2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively. Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration. Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury. Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4. Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser.
  • 基因功能参考文献：
    1. Data suggest that ganglioside glycosyltransferases ST3GAL5, ST8SIA1, and B4GALNT1 are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 and ST3Gal-II, dimer formation controls their S-acylation status. PMID: 28698248
    2. This suggests that the C-terminal domain of ST3Gal-II depends on N-glycosylation to attain an optimum conformation for proper exit from the endoplasmic reticulum PMID: 25916169
    3. Genomic structure, expression, and transcriptional regulation of ST3GALII. PMID: 12504121
    4. ST3Gal II is a MSGb5 (stage-specific embryonic antigen-4) synthase and its increased expression level is closely related to renal carcinogenesis PMID: 12716912
  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 组织特异性：
    Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney.
  • 数据库链接：

    HGNC: 10863

    OMIM: 607188

    KEGG: hsa:6483

    STRING: 9606.ENSP00000345477

    UniGene: Hs.368611