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  4. Recombinant Human CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (ST3GAL2), partial

Recombinant Human CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (ST3GAL2), partial

  • 中文名称：
    人ST3GAL2重组蛋白
  • 货号：
    CSB-YP618099HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ST3GAL2重组蛋白
  • 货号：
    CSB-EP618099HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ST3GAL2重组蛋白
  • 货号：
    CSB-EP618099HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ST3GAL2重组蛋白
  • 货号：
    CSB-BP618099HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ST3GAL2重组蛋白
  • 货号：
    CSB-MP618099HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ST3GAL2
  • Uniprot No.：
  • 别名：
    3-GalNAc-alpha-2; 3-sialyltransferase 2; 3-sialyltransferase; 3-ST 2; Alpha 2; Alpha 2,3-ST; Beta-galactoside alpha-2; Beta-galactoside alpha-2,3-sialyltransferase; CMP N-acetylneuraminate beta galactosamide alpha 2,3 sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2; Gal NAc6S; Gal-beta-1; Gal-NAc6S; SIA4B_HUMAN; sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase); Sialyltransferase 4B; SIAT4-B; SIAT4B; ST3 beta-galactoside alpha-2,3-sialyltransferase 2; ST3Gal II; ST3GAL2; ST3GalA.2; ST3GalII
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively. Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration. Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury. Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4. Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser.
  • 基因功能参考文献：
    1. Data suggest that ganglioside glycosyltransferases ST3GAL5, ST8SIA1, and B4GALNT1 are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 and ST3Gal-II, dimer formation controls their S-acylation status. PMID: 28698248
    2. This suggests that the C-terminal domain of ST3Gal-II depends on N-glycosylation to attain an optimum conformation for proper exit from the endoplasmic reticulum PMID: 25916169
    3. Genomic structure, expression, and transcriptional regulation of ST3GALII. PMID: 12504121
    4. ST3Gal II is a MSGb5 (stage-specific embryonic antigen-4) synthase and its increased expression level is closely related to renal carcinogenesis PMID: 12716912
  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 组织特异性：
    Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney.
  • 数据库链接：

    HGNC: 10863

    OMIM: 607188

    KEGG: hsa:6483

    STRING: 9606.ENSP00000345477

    UniGene: Hs.368611