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ST6GALNAC2 Antibody

  • 中文名称：
    ST6GALNAC2兔多克隆抗体
  • 货号：
    CSB-PA883452LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ST6GALNAC2 antibody at 8μg/ml + MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 42 kDa
      Observed band size: 42 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ST6GALNAC2 Polyclonal antibody
  • Uniprot No.：
    Q9UJ37
  • 基因名：
    ST6GALNAC2
  • 别名：
    ST6GALNAC2 antibody; SIAT7B antibody; SIATL1 antibody; STHMAlpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 antibody; EC 2.4.99.3 antibody; GalNAc alpha-2,6-sialyltransferase II antibody; ST6GalNAc II antibody; ST6GalNAcII antibody; SThM antibody; Sialyltransferase 7B antibody; SIAT7-B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 protein (101-374AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ST6GALNAC2 Antibody (CSB-PA883452LA01HU)，的标记方式是Non-conjugated。对于ST6GALNAC2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA883452LB01HU ST6GALNAC2 Antibody, HRP conjugated ELISA
    FITC CSB-PA883452LC01HU ST6GALNAC2 Antibody, FITC conjugated
    Biotin CSB-PA883452LD01HU ST6GALNAC2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.
  • 基因功能参考文献：
    1. MicroRNAs miR-135b and miR-182 may reverse the resistance to 5-fluorouracil (5-FU) in colorectal cancer (CRC) cells by targeting ST6GALNAC2 via PI3K/AKT pathway, which render potential chemotherapy targets for the treatment of CRC. PMID: 28767179
    2. miR-182/-135b/ST6GALNAC2/PI3K/AKT axis could function as regulator of progression in colorectal cancer PMID: 29030743
    3. Study provides evidence that mutations in B3GNT2, B4GALT2, and ST6GALNAC2 underlie aberrant glycosylation, and contribute to the pathogenesis of molecular subsets of colon and other gastrointestinal malignancies. PMID: 27004849
    4. Results provide evidence that ST6GalNAcII activated the invasion in follicular thyroid cancer cells through regulating the activity of PI3K/Akt pathway. PMID: 26820593
    5. High expression level of ST6GalNAcII is associated with invasive phenotype of breast cancer. PMID: 24756995
    6. ST6GalNAc II might be participated in the glycosylation of Axl, and this Axl glycosylation may mediate the tumorigenicity, invasion, and distant metastasis of breast phyllodes tumor cells. PMID: 24961352
    7. Results identified the sialyltransferase ST6GalNAc2 as a novel breast cancer metastasis suppressor. PMID: 24520024
    8. Il-6 and Il-4 reduced galactosylation of the O-glycan substrate directly via decreased expression of the galactosyltransferase C1GalT1 and, indirectly, via increased expression of the sialyltransferase ST6GalNAc-II PMID: 24398680
    9. ST6GalNAc2 is a novel enzyme that regulates leukocyte adhesion under fluid shear PMID: 23548905
    10. Expression of the ST6-GalNAcII gene and activity of the CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase were higher in immunoglobulinA1-producing cell lines. PMID: 17418236
    11. the ADG haplotype in the ST6GALNAC2 gene is a functional regulatory variant that may contribute to the genetic susceptibility in a subset of patients in whom the desialylation of IgA1 molecules was the main causative pathogenesis of IgAN PMID: 17480010
    12. reduced sialylation of serum IgA1 may result from decreased expression of ST6GALNAC2. PMID: 19170967
    13. potential genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgA nephropathy PMID: 19357720

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 组织特异性：
    Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.
  • 数据库链接：

    HGNC: 10867

    OMIM: 610137

    KEGG: hsa:10610

    STRING: 9606.ENSP00000225276

    UniGene: Hs.592105