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SUMF2 Antibody

  • 货号：
    CSB-PA839844LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate, U87 whole cell lysate, Hela whole cell lysate
      All lanes: SUMF2 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 34, 25, 38, 24, 35 kDa
      Observed band size: 34 kDa
    • Immunoprecipitating SUMF2 in Hela whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-PA839844LA01HU in Hela whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/50000)
      Lane 2: CSB-PA839844LA01HU (5ug) + Hela whole cell lysate (500ug)
      Lane 3: Hela whole cell lysate (10ug)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SUMF2 Polyclonal antibody
  • Uniprot No.：
    Q8NBJ7
  • 基因名：
    SUMF2
  • 别名：
    SUMF2 antibody; PSEC0171 antibody; UNQ1968/PRO4500 antibody; Inactive C-alpha-formylglycine-generating enzyme 2 antibody; Paralog of formylglycine-generating enzyme antibody; pFGE antibody; Sulfatase-modifying factor 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sulfatase-modifying factor 2 protein (26-301AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SUMF2 Antibody (CSB-PA839844LA01HU)，的标记方式是Non-conjugated。对于SUMF2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA839844LB01HU SUMF2 Antibody, HRP conjugated ELISA
    FITC CSB-PA839844LC01HU SUMF2 Antibody, FITC conjugated
    Biotin CSB-PA839844LD01HU SUMF2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Antigen Affinity purified & Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IP 1:1000-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.
  • 基因功能参考文献：
    1. SUMF2 interacted with IL-13 and inhibited IL-13 secretion in bronchial smooth muscle cells and lymphocytes, which was independent of IL-13 glycosylation PMID: 19739097
    2. structural analysis of human pFGE by X-ray crystallography [pFGE] PMID: 15687489
    3. pFGE (SUMF2) is the paralog of the Calpha-formylglycine-generating enzyme PMID: 15708861
    4. SUMF2 interacts with sulphatase-modifying factor 1 to regulate sulphatase activities. PMID: 15962010
    5. pFGE is retained in the ER through its C-terminal tetrapeptide PGEL, a noncanonical variant of the classic KDEL ER-retention signal. PMID: 18266766

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  • 亚细胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Sulfatase-modifying factor family
  • 组织特异性：
    Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in kidney, liver and placenta.
  • 数据库链接：

    HGNC: 20415

    OMIM: 607940

    KEGG: hsa:25870

    STRING: 9606.ENSP00000341938

    UniGene: Hs.279696