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SYNCRIP Antibody

  • 货号：
    CSB-PA03334A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SYNCRIP antibody at 2µg/ml
      Lane 1: EC109 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 70, 66, 63, 59, 47 kDa
      Observed band size: 70, 36 kDa
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA03334A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA03334A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SYNCRIP Polyclonal antibody
  • Uniprot No.：
    O60506
  • 基因名：
    SYNCRIP
  • 别名：
    cytoplasmic RNA-interacting protein antibody; dJ3J17.2 antibody; Glycine and tyrosine rich RNA binding protein antibody; Glycine- and tyrosine-rich RNA-binding protein antibody; GRY RBP antibody; GRY-RBP antibody; GRYRBP antibody; Heterogeneous nuclear ribonucleoprotein Q antibody; hnRNP Q antibody; HNRPQ antibody; HNRPQ_HUMAN antibody; HNRPQ1 antibody; NS1 associated protein 1 antibody; NS1-associated protein 1 antibody; NSAP1 antibody; pp68 antibody; RP1 3J17.2 antibody; Synaptotagmin binding cytoplasmic RNA interacting protein antibody; Synaptotagmin-binding antibody; Syncrip antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Heterogeneous nuclear ribonucleoprotein Q protein (2-191AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SYNCRIP Antibody (CSB-PA03334A0Rb)，的标记方式是Non-conjugated。对于SYNCRIP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA03334B0Rb SYNCRIP Antibody, HRP conjugated ELISA
    FITC CSB-PA03334C0Rb SYNCRIP Antibody, FITC conjugated
    Biotin CSB-PA03334D0Rb SYNCRIP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.
  • 基因功能参考文献：
    1. A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets. PMID: 29483512
    2. our data indicate that hnRNP Q1 is a novel trans-acting factor that binds to Aurora-A mRNA 5'-UTRs and regulates its translation, which increases cell proliferation and contributes to tumorigenesis in colorectal cancer PMID: 28079881
    3. SYNCRIP is required for survival of leukemia cells. SYNCRIP controls the myeloid leukemia stem cell program. PMID: 28436985
    4. The acidic domain is a unique structural feature of the splicing factor SYNCRIP. PMID: 27081926
    5. hnRNPQ6 is required for APOBEC1-enhanced IL8 production. PMID: 25100733
    6. The hnRNP Q is a novel substrate of SHP2 and the SHP2 activity may be also involved in RNA metabolisms via dephosphorylation of hnRNP Q. PMID: 23946508
    7. The inhibitory effect of hnRNP Q on YB-1 mRNA translation can be explained by its ability to pro-mote YB-1 binding to the regulatory element within the YB-1 mRNA 3' UTR. PMID: 23980891
    8. These data indicate that hnRNP Q can stimulate the protein production of HIV-1 Rev-dependent mRNAs without changing mRNA levels and mRNA export, respectively. PMID: 23679954
    9. Data demonstrate that expression levels of hnRNP A1, Q, K, R, and U influence HIV-1 production by persistently infected PMID: 19808671
    10. The overexpression of NSAP1 specifically enhanced HCV IRES-dependent translation, and knockdown of NSAP1 by use of a small interfering RNA specifically inhibited the translation of HCV mRNA. PMID: 15340051
    11. SYNCRIP is transported within the dendrite as a component of mRNA granules PMID: 15475564
    12. methylation of hnRNPQ is important for its nuclear localization PMID: 16765914
    13. Results suggest hnRNPQ interacts via its acidic domain (AcD) with Apobec1 and that this interaction is regulated by AcD phosphorylation. PMID: 17010310
    14. Data demonstrate that hnRNP Q is a splicing modulator of SMN2, further underscoring the potential of hnRNP Q as a therapeutic target for spinal muscular atrophy. PMID: 18794368
    15. Results demonstrate that galectin-3 stabilizes hnRNP Q via complex formation, and reduction in the hnRNP Q level leads to slow proliferation and less susceptibility to 5-FU. PMID: 19137262
    16. SYNCRIP participates in both RNA replication and translation in HCV life cycle. PMID: 19232660

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  • 亚细胞定位：
    Cytoplasm. Microsome. Endoplasmic reticulum. Nucleus.; [Isoform 1]: Nucleus, nucleoplasm.; [Isoform 2]: Nucleus, nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm.
  • 组织特异性：
    Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.
  • 数据库链接：

    HGNC: 16918

    KEGG: hsa:10492

    STRING: 9606.ENSP00000358635

    UniGene: Hs.571177