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SYT2 Antibody

  • 中文名称：
    SYT2兔多克隆抗体
  • 货号：
    CSB-PA118294
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal brain tissue, Human lung tissue, Primary antibody: CSB-PA118294(SYT2 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q8N9I0
  • 基因名：
    SYT2
  • 别名：
    Synaptotagmin 2 antibody; Synaptotagmin II antibody; Synaptotagmin-2 antibody; Synaptotagmin2 antibody; SynaptotagminII antibody; SYT 2 antibody; Syt II antibody; Syt2 antibody; SYT2_HUMAN antibody; SytII antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human SYT2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes.
  • 基因功能参考文献：
    1. SYT2 mutations cause a novel complex presynaptic congenital myasthenic syndrome characterized by motor neuropathy causing lower limb wasting and foot deformities, reflex potentiation following exercise and a prolonged period of posttetanic potentiation PMID: 26519543
    2. Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy. PMID: 25192047
    3. Human SytII is not an effective receptor for Botulinum neurotoxin D-C. PMID: 22454523
    4. synaptotagmin-II is not a high affinity receptor for BoNT/B and G due to a phenylalanine to leucine mutation in its luminal domain present only in humans and chimpanzees PMID: 22265973
    5. role for synaptotagmin II as calcium-sensor during phagocytosis and secretion in neutrophils PMID: 12063179
    6. both synaptotagmins I and II can interact with the syntaxin/synaptosomal-associated protein of 25 kDa (SNAP-25) dimer PMID: 14709554
    7. A recombinant fragment from the luminal domain of the human receptor protein syt II can bind specifically to botulinum neurotoxin B and its Hc domain. PMID: 18639519
    8. Mutation of overexpressed Syt2 transgene leaves intrinsic calcium sensitivity of vesicles intact while it destabilizes the readily releasable pool of vesicles and loosens the tight coupling between calcium influx and release. PMID: 19709630

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  • 相关疾病：
    Myasthenic syndrome, congenital, 7, presynaptic (CMS7)
  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein.
  • 蛋白家族：
    Synaptotagmin family
  • 组织特异性：
    Expressed in melanocytes.
  • 数据库链接：

    HGNC: 11510

    OMIM: 600104

    KEGG: hsa:127833

    STRING: 9606.ENSP00000356236

    UniGene: Hs.25422