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  4. TAGAP Antibody

TAGAP Antibody

  • 货号：
    CSB-PA006897
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8N103
  • 基因名：
    TAGAP
  • 别名：
    2610315E15Rik antibody; ARHGAP47 antibody; FKSG15 antibody; FLJ32631 antibody; FLJ39771 antibody; IDDM21 antibody; MGC133247 antibody; MGC27381 antibody; MGC31468 antibody; T cell activation GTPase activating protein antibody; T cell activation Rho GTPase activating protein antibody; T-cell activation GTPase-activating protein antibody; T-cell activation Rho GTPase-activating protein antibody; Tagap antibody; TAGAP_HUMAN antibody; TAGAP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TAGAP.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May function as a GTPase-activating protein and may play important roles during T-cell activation.
  • 基因功能参考文献：
    1. This is the first comprehensive study, where TAGAP gene variants were analyzed using in silico tools hence will be of great help while considering large scale studies and also in developing precision medicines for cure of diseases related to these polymorphisms PMID: 29329296
    2. Results suggested that TAGAP rs1738074 polymorphism could be considered as a risk factor in the prevalence of multiple sclerosis in the Iranian population PMID: 28356229
    3. meta-analysis provides robust estimates that polymorphisms in LPP and TAGAP genes are potential risk factors for celiac disease in Europeans and Americans PMID: 28208589
    4. IL2RA and TAGAP are novel vitamin D target genes. The vitamin D response is observed in samples from both the multiple sclerosis (MS) patients and controls, and is not dependent on the genotype of MS-associated SNPs in the respective genes. PMID: 26765264
    5. SNPs in TAGAP are associated with increased risk of candidemia. PMID: 25197941
    6. Colonic expression of TAGAP in Crohn's disease varies according to disease severity and location, being the most elevated in patients with severe disease in the sigmoid colon PMID: 24582067
    7. we suggest that polymorphism rs212389 better predicts the association of TAGAP locus with RA. PMID: 23453471
    8. Rs212388 single nucleotide polymorphism most significantly correlated with the presence and severity of anal disease in ileocolonic Crohn's disease. PMID: 23044675
    9. SNPs in regulatory regions of TAGAP and an intronic SNP (TNFAIP3) are potential susceptibility loci in African Americans. PMID: 22127930
    10. study has refined the TAGAP signal of association to a single haplotype in rheumatoid arthritis (RA), and in doing so provides conclusive statistical evidence that the TAGAP locus is associated with RA risk PMID: 21390051
    11. there is strong evidence that variation within the TAGAP gene is associated with rheumatoid arthritis, type 1 diabetes and coeliac disease PMID: 20854658

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  • 数据库链接：

    HGNC: 15669

    OMIM: 609667

    KEGG: hsa:117289

    STRING: 9606.ENSP00000356033

    UniGene: Hs.529984