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  4. Recombinant Human T-cell activation Rho GTPase-activating protein (TAGAP)

Recombinant Human T-cell activation Rho GTPase-activating protein (TAGAP)

  • 中文名称：
    人TAGAP重组蛋白
  • 货号：
    CSB-YP818676HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TAGAP重组蛋白
  • 货号：
    CSB-EP818676HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TAGAP重组蛋白
  • 货号：
    CSB-EP818676HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TAGAP重组蛋白
  • 货号：
    CSB-BP818676HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TAGAP重组蛋白
  • 货号：
    CSB-MP818676HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TAGAP
  • Uniprot No.：
  • 别名：
    2610315E15Rik; ARHGAP47; FKSG15; FLJ32631; FLJ39771; IDDM21; MGC133247; MGC27381; MGC31468; T cell activation GTPase activating protein; T cell activation Rho GTPase activating protein; T-cell activation GTPase-activating protein; T-cell activation Rho GTPase-activating protein; Tagap; TAGAP_HUMAN; TAGAP1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-731
  • 氨基酸序列
    MKLRSSHNAS KTLNANNMET LIECQSEGDI KEHPLLASCE SEDSICQLIE VKKRKKVLSW PFLMRRLSPA SDFSGALETD LKASLFDQPL SIICGDSDTL PRPIQDILTI LCLKGPSTEG IFRRAANEKA RKELKEELNS GDAVDLERLP VHLLAVVFKD FLRSIPRKLL SSDLFEEWMG ALEMQDEEDR IEALKQVADK LPRPNLLLLK HLVYVLHLIS KNSEVNRMDS SNLAICIGPN MLTLENDQSL SFEAQKDLNN KVKTLVEFLI DNCFEIFGEN IPVHSSITSD DSLEHTDSSD VSTLQNDSAY DSNDPDVESN SSSGISSPSR QPQVPMATAA GLDSAGPQDA REVSPEPIVS TVARLKSSLA QPDRRYSEPS MPSSQECLES RVTNQTLTKS EGDFPVPRVG SRLESEEAED PFPEEVFPAV QGKTKRPVDL KIKNLAPGSV LPRALVLKAF SSSSLDASSD SSPVASPSSP KRNFFSRHQS FTTKTEKGKP SREIKKHSMS FTFAPHKKVL TKNLSAGSGK SQDFTRDHVP RGVRKESQLA GRIVQENGCE THNQTARGFC LRPHALSVDD VFQGADWERP GSPPSYEEAM QGPAARLVAS ESQTVGSMTV GSMRARMLEA HCLLPPLPPA HHVEDSRHRG SKEPLPGHGL SPLPERWKQS RTVHASGDSL GHVSGPGRPE LLPLRTVSES VQRNKRDCLV RRCSQPVFEA DQFQYAKESY I
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function as a GTPase-activating protein and may play important roles during T-cell activation.
  • 基因功能参考文献：
    1. This is the first comprehensive study, where TAGAP gene variants were analyzed using in silico tools hence will be of great help while considering large scale studies and also in developing precision medicines for cure of diseases related to these polymorphisms PMID: 29329296
    2. Results suggested that TAGAP rs1738074 polymorphism could be considered as a risk factor in the prevalence of multiple sclerosis in the Iranian population PMID: 28356229
    3. meta-analysis provides robust estimates that polymorphisms in LPP and TAGAP genes are potential risk factors for celiac disease in Europeans and Americans PMID: 28208589
    4. IL2RA and TAGAP are novel vitamin D target genes. The vitamin D response is observed in samples from both the multiple sclerosis (MS) patients and controls, and is not dependent on the genotype of MS-associated SNPs in the respective genes. PMID: 26765264
    5. SNPs in TAGAP are associated with increased risk of candidemia. PMID: 25197941
    6. Colonic expression of TAGAP in Crohn's disease varies according to disease severity and location, being the most elevated in patients with severe disease in the sigmoid colon PMID: 24582067
    7. we suggest that polymorphism rs212389 better predicts the association of TAGAP locus with RA. PMID: 23453471
    8. Rs212388 single nucleotide polymorphism most significantly correlated with the presence and severity of anal disease in ileocolonic Crohn's disease. PMID: 23044675
    9. SNPs in regulatory regions of TAGAP and an intronic SNP (TNFAIP3) are potential susceptibility loci in African Americans. PMID: 22127930
    10. study has refined the TAGAP signal of association to a single haplotype in rheumatoid arthritis (RA), and in doing so provides conclusive statistical evidence that the TAGAP locus is associated with RA risk PMID: 21390051
    11. there is strong evidence that variation within the TAGAP gene is associated with rheumatoid arthritis, type 1 diabetes and coeliac disease PMID: 20854658

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  • 数据库链接：

    HGNC: 15669

    OMIM: 609667

    KEGG: hsa:117289

    STRING: 9606.ENSP00000356033

    UniGene: Hs.529984