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TENC1 Antibody

  • 货号：
    CSB-PA100789
  • 规格：
    ￥880
  • 图片：
    • Western blot analysis of A549 3T3 using Tensin-2 antibody. Antibody was diluted at 1:500. Secondary antibody was diluted at 1:20000
  • 其他：

产品详情

  • Uniprot No.：
    Q63HR2
  • 基因名：
    TNS2
  • 别名：
    C1 domain containing phosphatase and tensin homolog antibody; C1 domain-containing phosphatase and tensin homolog antibody; C1 TEN antibody; C1-TEN antibody; C1TEN antibody; DKFZp686D13244 antibody; FLJ16320 antibody; KIAA1075 antibody; TENC 1 antibody; TENC1 antibody; TENC1_HUMAN antibody; Tensin 2 antibody; Tensin like C1 domain containing phosphatase antibody; Tensin-2 antibody; Tensin-like C1 domain-containing phosphatase antibody; TNS2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human Tensin-2 around the non-phosphorylation site of Y483.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin. In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy. Negatively regulates PI3K-AKT pathway activation.
  • 基因功能参考文献：
    1. Patients with low TNS2 expression showed poor relapse-free survival rates for breast and lung cancers. These results strongly suggest a role of tensin2 in suppressing cell transformation and reduction of tumorigenicity. PMID: 27203214
    2. p62 expression increased but C1-Ten protein decreased during muscle differentiation, supporting a role for p62 as a physiological regulator of C1-Ten. PMID: 25101860
    3. Pulldown studies in human cells using Myc-tagged Tensin2 constructs revealed that DISC1 specifically interacts with the C-terminal PTB domain of Tensin2 in a phosphorylation-independent manner. PMID: 23233134
    4. Results identified tensin2 as a Syk-binding protein. PMID: 22019427
    5. Here, we report complete chemical shift assignments of the SH2 domain of human tensin2 determined by triple resonance experiments. PMID: 21461930
    6. Tensin2 is an important new mediator in TPO/c-Mpl pathway and has a positive affect on cellular growth, at least in part through its effect on the PI3K/Akt signaling. PMID: 21527831
    7. Tensin2 SH2 domain was identified to interact with nonphosphorylated ligand (DLC-1) as well as phosphorylated ligand. PMID: 21765928
    8. Tensin2, in addition to regulating cytoskeletal dynamics, influences phosphoinositide-Akt signalling through its PTPase domain. PMID: 20678486
    9. Data suggest that the interaction between START-GAP1 and tensin2 occurs in a PTB domain-dependent manner. manner.ty=0 PMID: 19895840
    10. Differential proteolytic cleavage of Tensin2 can liberate domains with discrete localisations and functions, which has implications for the role of Tensins in cancer cell survival and motility. PMID: 19747564
    11. Interaction of Axl receptor tyrosine kinase with C1-TEN. PMID: 12470648
    12. C1 domain-containing phosphatase and TENsin homologue (C1-TEN) appears to be a novel intracellular phosphatase that negatively regulates the Akt/Protein kinase B signaling cascade PMID: 15817639
    13. variant 3 significantly promoted the cell growth and motility of HCC cells; clonal transfectants of variant 3 were more closely packed and resulted in a higher saturation density than in the control vector transfectants PMID: 17006924
    14. Tensins may represent a novel group of metastasis suppressors in the kidney, the loss of which leads to greater tumor cell motility and consequent metastasis. PMID: 19194507
    15. DLC1 interaction with tensin2 through this novel focal adhesion binding site contributes to the growth-suppressive activity of DLC1. PMID: 19440389

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  • 亚细胞定位：
    Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 组织特异性：
    Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.
  • 数据库链接：

    HGNC: 19737

    OMIM: 607717

    KEGG: hsa:23371

    STRING: 9606.ENSP00000319756

    UniGene: Hs.343334