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TGM4 Antibody

  • 货号：
    CSB-PA023464LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA023464LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of SH-SY5Y cells with CSB-PA023464LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TGM4 Polyclonal antibody
  • Uniprot No.：
    P49221
  • 基因名：
    TGM4
  • 别名：
    Dorsal prostate transglutaminase antibody; Dorsal protein 1 antibody; Dp1 antibody; Fibrinoligase antibody; hTGP antibody; Prostate specific transglutaminase antibody; Prostate transglutaminase antibody; Prostate-specific transglutaminase antibody; Protein glutamine gamma glutamyltransferase 4 antibody; Protein-glutamine gamma-glutamyltransferase 4 antibody; TG(P) antibody; TGase P antibody; TGase-4 antibody; TGase4 antibody; Tgm4 antibody; TGM4_HUMAN antibody; TGP antibody; Transglutaminase 4 (prostate) antibody; Transglutaminase 4 antibody; Transglutaminase P antibody; Transglutaminase, prostate antibody; Transglutaminase-4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein-glutamine gamma-glutamyltransferase 4 protein (1-684AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TGM4 Antibody (CSB-PA023464LA01HU)，的标记方式是Non-conjugated。对于TGM4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023464LB01HU TGM4 Antibody, HRP conjugated ELISA
    FITC CSB-PA023464LC01HU TGM4 Antibody, FITC conjugated
    Biotin CSB-PA023464LD01HU TGM4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
  • 基因功能参考文献：
    1. TGM4 is a prostatic secretory molecule with critical role in male reproduction. PMID: 26084804
    2. indicated that transglutaminase 4 may serve as a potential predictor of biochemical recurrence of prostate cancer PMID: 23974364
    3. Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the hTGP gene and that presence of the androgen receptor, but not its transcriptional transactivation activity, is critical for hTGP transcription. PMID: 22362749
    4. CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands PMID: 21743959
    5. The presence of TGase-4 has a biological impact on a prostate cancer cell's response to MDA-7. PMID: 21524313
    6. TGase-4 expression is intrinsically linked to the activation of RON in prostate cancer cells and that this autoactivation of RON contributes to the increased cell motility in TGase-4 expressing cells. PMID: 20596668
    7. The expression status of human transglutaminase 4 in benign prostate hyperplasia (BPH) and prostate cancer was analyzed. PMID: 20177144
    8. transglutaminase 4 has a relatively wide profile of expression in human cancer cell lines PMID: 17552366
    9. TGase-4 plays a pivotal role in the interaction between endothelial cells and prostate cancer cells, an action which is independent of the ROCK pathway. PMID: 18983858

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  • 蛋白家族：
    Transglutaminase superfamily, Transglutaminase family
  • 组织特异性：
    Prostate.
  • 数据库链接：

    HGNC: 11780

    OMIM: 600585

    KEGG: hsa:7047

    STRING: 9606.ENSP00000296125

    UniGene: Hs.438265