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TGM4 Antibody

  • 货号：
    CSB-PA038312
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA038312(TGM4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA038312(TGM4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Hela, lncap, skov3, 293T and TM4 cell, Primary antibody: CSB-PA038312(TGM4 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P49221
  • 基因名：
    TGM4
  • 别名：
    Dorsal prostate transglutaminase antibody; Dorsal protein 1 antibody; Dp1 antibody; Fibrinoligase antibody; hTGP antibody; Prostate specific transglutaminase antibody; Prostate transglutaminase antibody; Prostate-specific transglutaminase antibody; Protein glutamine gamma glutamyltransferase 4 antibody; Protein-glutamine gamma-glutamyltransferase 4 antibody; TG(P) antibody; TGase P antibody; TGase-4 antibody; TGase4 antibody; Tgm4 antibody; TGM4_HUMAN antibody; TGP antibody; Transglutaminase 4 (prostate) antibody; Transglutaminase 4 antibody; Transglutaminase P antibody; Transglutaminase, prostate antibody; Transglutaminase-4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human TGM4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
  • 基因功能参考文献：
    1. TGM4 is a prostatic secretory molecule with critical role in male reproduction. PMID: 26084804
    2. indicated that transglutaminase 4 may serve as a potential predictor of biochemical recurrence of prostate cancer PMID: 23974364
    3. Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the hTGP gene and that presence of the androgen receptor, but not its transcriptional transactivation activity, is critical for hTGP transcription. PMID: 22362749
    4. CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands PMID: 21743959
    5. The presence of TGase-4 has a biological impact on a prostate cancer cell's response to MDA-7. PMID: 21524313
    6. TGase-4 expression is intrinsically linked to the activation of RON in prostate cancer cells and that this autoactivation of RON contributes to the increased cell motility in TGase-4 expressing cells. PMID: 20596668
    7. The expression status of human transglutaminase 4 in benign prostate hyperplasia (BPH) and prostate cancer was analyzed. PMID: 20177144
    8. transglutaminase 4 has a relatively wide profile of expression in human cancer cell lines PMID: 17552366
    9. TGase-4 plays a pivotal role in the interaction between endothelial cells and prostate cancer cells, an action which is independent of the ROCK pathway. PMID: 18983858

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  • 蛋白家族：
    Transglutaminase superfamily, Transglutaminase family
  • 组织特异性：
    Prostate.
  • 数据库链接：

    HGNC: 11780

    OMIM: 600585

    KEGG: hsa:7047

    STRING: 9606.ENSP00000296125

    UniGene: Hs.438265