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THOC6 Antibody

  • 中文名称：
    THOC6兔多克隆抗体
  • 货号：
    CSB-PA769793LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, SH-SY5Y whole cell lysate
      All lanes: THOC6 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 38, 35, 33 kDa
      Observed band size: 35 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) THOC6 Polyclonal antibody
  • Uniprot No.：
    Q86W42
  • 基因名：
    THOC6
  • 别名：
    THOC6 antibody; WDR58 antibody; PSEC0006 antibody; THO complex subunit 6 homolog antibody; Functional spliceosome-associated protein 35 antibody; fSAP35 antibody; WD repeat-containing protein 58 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human THO complex subunit 6 homolog protein (56-315AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，THOC6 Antibody (CSB-PA769793LA01HU)，的标记方式是Non-conjugated。对于THOC6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA769793LB01HU THOC6 Antibody, HRP conjugated ELISA
    FITC CSB-PA769793LC01HU THOC6 Antibody, FITC conjugated
    Biotin CSB-PA769793LD01HU THOC6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.
  • 基因功能参考文献：
    1. Results indicate three unrelated patients with bi-allelic mutations in THOC6 associated with intellectual disability and additional clinical features. PMID: 27102954
    2. In addition to confirming the morbid nature of THOC6 by providing an independent homozygous apparently loss of function allele in a patient with a compatible phenotype, our data also expand THOC6-related phenotype to include previously unreported imperforate anus and undescended testicles. PMID: 26739162
  • 相关疾病：
    Beaulieu-Boycott-Innes syndrome (BBIS)
  • 亚细胞定位：
    Nucleus. Nucleus speckle.
  • 蛋白家族：
    WD repeat THOC6 family
  • 数据库链接：

    HGNC: 28369

    OMIM: 613680

    KEGG: hsa:79228

    STRING: 9606.ENSP00000326531

    UniGene: Hs.412304