Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. TLR13 Antibody

TLR13 Antibody

  • 中文名称：
    TLR13兔多克隆抗体
  • 货号：
    CSB-PA080183
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded Mouse Spleen Tissue using TLR13 Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q6R5N8
  • 基因名：
    Tlr13
  • 别名：
    Tlr13 antibody; Toll-like receptor 13 antibody; EC 3.2.2.6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Recombinant Protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-500
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences.
  • 基因功能参考文献：
    1. Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA has been presented. PMID: 26676765
    2. S. pyogenes is initially recognized in a phagocytosis-independent manner by TLR2 and subsequently by TLR13 upon internalization. PMID: 25756897
    3. TLR13 expressed by immune cells detects bacterial RNA with exquisite sequence specificity. PMID: 23110254
    4. These data lend support to the conclusion that TLR13 participates in group B streptococcus recognition, although blockade of the function of this receptor can be compensated for by other endosomal toll-like receptors. PMID: 25225249
    5. TLR13 activation contributes to the innate response to Gram-positive bacteria, identifying TLR13 as a receptor for bacterial RNA. PMID: 22896636
    6. these results show that the orphan receptor TLR13 in mice recognizes a conserved 23S ribosomal RNA (rRNA) sequence that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria. Notably PMID: 22821982
    7. the potential role of the novel Toll-like receptor tlr13 in the recognition of viral infection. PMID: 21131352
    8. These findings reveal the mechanism of Tlr13 gene regulation, thereby providing insight into the function of Tlr13 in the immune response to pathogen. PMID: 19487701

    显示更多

    收起更多

  • 亚细胞定位：
    Endosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Toll-like receptor family
  • 数据库链接：

    KEGG: mmu:279572

    STRING: 10090.ENSMUSP00000043101

    UniGene: Mm.336203