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TMEM88 Antibody

  • 货号：
    CSB-PA023892LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of A549 cells with CSB-PA023892LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TMEM88 Polyclonal antibody
  • Uniprot No.：
    Q6PEY1
  • 基因名：
    TMEM88
  • 别名：
    TMEM88; TMEM88A; Transmembrane protein 88
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transmembrane protein 88 protein (109-159AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TMEM88 Antibody (CSB-PA023892LA01HU)，的标记方式是Non-conjugated。对于TMEM88 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023892LB01HU TMEM88 Antibody, HRP conjugated ELISA
    FITC CSB-PA023892LC01HU TMEM88 Antibody, FITC conjugated
    Biotin CSB-PA023892LD01HU TMEM88 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.
  • 基因功能参考文献：
    1. TMEM88 inhibits the TGF-beta1-stimulated cell proliferation, migration and extracellular matrix expression in keloid fibroblasts. PMID: 28946191
    2. TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival PMID: 28718365
    3. Results support that OC platinum resistance was correlated with TMEM88 overexpression regulated through decreased promoter methylation. Data suggest that TMEM88 functions as an inhibitor of Wnt signaling, contributing to the development of platinum resistance. PMID: 27374141
    4. TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVL1. PMID: 26325443
    5. mislocalization of TMEM88 to the cytosol in non-small cell lung cancer cells ablates its Wnt pathway regulatory properties, thereby promoting invasion and metastasis by activating the p38-GSK3beta-Snail signaling pathway. PMID: 26359454
    6. TMEM88 is crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte. PMID: 23924634
    7. miRNA-708 acts as an oncogene contributing to tumor growth and disease progression by directly downregulating TMEM88 PMID: 22573352
    8. TMEM88 associates with Dvl proteins and regulates Wnt signaling in a context-dependent manner PMID: 21044957

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    TMEM88 family
  • 数据库链接：

    HGNC: 32371

    OMIM: 617813

    KEGG: hsa:92162

    STRING: 9606.ENSP00000301599

    UniGene: Hs.389669