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  4. Recombinant Human Transmembrane protein 88 (TMEM88)

Recombinant Human Transmembrane protein 88 (TMEM88)

  • 中文名称：
    人TMEM88重组蛋白
  • 货号：
    CSB-CF023892HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    TMEM88
  • Uniprot No.：
  • 别名：
    TMEM88; TMEM88A; Transmembrane protein 88
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-159
  • 氨基酸序列
    MADVPGAQRAVPGDGPEPRDPLDCWACAVLVTAQNLLVAAFNLLLLVLVLGTILLPAVTM LGFGFLCHSQFLRSQAPPCTAHLRDPGFTALLVTGFLLLVPLLVLALASYRRLCLRLRLA DCLVPYSRALYRRRRAPQPRQIRASPGSQAVPTSGKVWV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.
  • 基因功能参考文献：
    1. TMEM88 inhibits the TGF-beta1-stimulated cell proliferation, migration and extracellular matrix expression in keloid fibroblasts. PMID: 28946191
    2. TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival PMID: 28718365
    3. Results support that OC platinum resistance was correlated with TMEM88 overexpression regulated through decreased promoter methylation. Data suggest that TMEM88 functions as an inhibitor of Wnt signaling, contributing to the development of platinum resistance. PMID: 27374141
    4. TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVL1. PMID: 26325443
    5. mislocalization of TMEM88 to the cytosol in non-small cell lung cancer cells ablates its Wnt pathway regulatory properties, thereby promoting invasion and metastasis by activating the p38-GSK3beta-Snail signaling pathway. PMID: 26359454
    6. TMEM88 is crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte. PMID: 23924634
    7. miRNA-708 acts as an oncogene contributing to tumor growth and disease progression by directly downregulating TMEM88 PMID: 22573352
    8. TMEM88 associates with Dvl proteins and regulates Wnt signaling in a context-dependent manner PMID: 21044957

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    TMEM88 family
  • 数据库链接：

    HGNC: 32371

    OMIM: 617813

    KEGG: hsa:92162

    STRING: 9606.ENSP00000301599

    UniGene: Hs.389669