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TNS4 Antibody

  • 货号：
    CSB-PA810319LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA810319LA01HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, PC-3 whole cell lysate, A549 whole cell lysate
      All lanes: TNS4 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 77 kDa
      Observed band size: 77 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TNS4 Polyclonal antibody
  • Uniprot No.：
    Q8IZW8
  • 基因名：
    TNS4
  • 别名：
    C terminal tensin like antibody; C terminal tensin like protein antibody; C-terminal tensin-like protein antibody; CTEN antibody; FLJ14950 antibody; PP14434 antibody; TENS4_HUMAN antibody; Tensin 4 antibody; Tensin-4 antibody; Tns4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Tensin-4 protein (20-231AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TNS4 Antibody (CSB-PA810319LA01HU)，的标记方式是Non-conjugated。对于TNS4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA810319LB01HU TNS4 Antibody, HRP conjugated ELISA
    FITC CSB-PA810319LC01HU TNS4 Antibody, FITC conjugated
    Biotin CSB-PA810319LD01HU TNS4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. May promote apoptosis, via its cleavage by caspase-3.
  • 基因功能参考文献：
    1. CTEN activated the expression of TGFB1, thereby prompting epithelial-mesenchymal transition in lung adenocarcinoma cancer cells. PMID: 29985912
    2. Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1. PMID: 29102927
    3. Cten-Snail signaling pathway contributes to cell motility in colorectal cancer (CRC), mediated by the stabilization of Snail protein. PMID: 28691764
    4. Conclude that in colorectal cancer, Cten is upregulated by EGFR and Kras but downregulated by STAT3. PMID: 26852686
    5. Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma PMID: 26035355
    6. Cten expression mediates invasion of human lung cancer cells and is upregulated by epidermal growth factor via STAT3. PMID: 25439778
    7. Findings indicate that induction of Cten protein expression is a relatively early event in melanoma progression, and that Cten has the potential to serve as a prognostic marker for primary melanoma patients. PMID: 24244691
    8. Up-regulated cten modulates cell migration induced by FGF2. PMID: 23625726
    9. Significant correlation between MET and TNS4 expression in human colon carcinoma and ovarian carcinoma suggests TNS4 plays a critical role in MET stability in cancer. PMID: 24814316
    10. CTEN regulates EGFR protein levels through a posttranslational mechanism. PMID: 23774213
    11. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. PMID: 23500447
    12. Show an oncogenic role for CTEN in pancreatic cancer through promotion of colony formation and cell motility. PMID: 22750970
    13. conclude that, in the colon and pancreas, Cten is a downstream target of Kras and may be a mechanism through which Kras regulates of cell motility PMID: 21698197
    14. Cten expression is of prognostic significance in colorectal carcinoma, and delineate a Cten-ILK pathway controlling cell motility and possibly promoting metastasis. PMID: 21339732
    15. CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma. PMID: 20390342
    16. Increased cten mRNA expression was correlated with tumor progression in lung cancers PMID: 12711115
    17. Cten/GAPDH mRNA expression was correlated with evidence of tumor progression in thymoma. PMID: 15001839
    18. These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity. PMID: 17190795
    19. Expression of CTEN correlates with high tumor grade and metastasis to lymph nodes, suggesting that CTEN may contribute to tumor invasiveness. PMID: 17765673
    20. TNS4 mRNA expression was significantly higher in gastric cancer. PMID: 18612693
    21. Cten is a novel nuclear partner of beta-catenin, and has an oncogenic activity in colon cancers. PMID: 19487278
    22. CTEN plays an important role in paclitaxel sensitivity, and CTEN expression level may be a prognostic predictive factor for prostate cancer patients. PMID: 19725034

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  • 亚细胞定位：
    Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Prostate and placenta. Down regulated in prostate cancer.
  • 数据库链接：

    HGNC: 24352

    OMIM: 608385

    KEGG: hsa:84951

    STRING: 9606.ENSP00000254051

    UniGene: Hs.438292