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  4. Recombinant Human Tensin-4 (TNS4)

Recombinant Human Tensin-4 (TNS4)

  • 货号：
    CSB-YP810319HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP810319HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP810319HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP810319HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP810319HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TNS4
  • Uniprot No.：
  • 别名：
    C terminal tensin like; C terminal tensin like protein; C-terminal tensin-like protein; CTEN; FLJ14950; PP14434; TENS4_HUMAN; Tensin 4; Tensin-4; Tns4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-715
  • 氨基酸序列
    AP CDEPRRTLHP APSPSLPPQC SYYTTEGWGA QALMAPVPCM GPPGRLQQAP QVEAKATCFL PSPGEKALGT PEDLDSYIDF SLESLNQMIL ELDPTFQLLP PGTGGSQAEL AQSTMSMRKK EESEALDIKY IEVTSARSRC HDGPQHCSSP SVTPPFGSLR SGGLLLSRDV PRETRSSSES LIFSGNQGRG HQRPLPPSEG LSPRPPNSPS ISIPCMGSKA SSPHGLGSPL VASPRLEKRL GGLAPQRGSR ISVLSASPVS DVSYMFGSSQ SLLHSSNSSH QSSSRSLESP ANSSSSLHSL GSVSLCTRPS DFQAPRNPTL TMGQPRTPHS PPLAKEHASS CPPSITNSMV DIPIVLINGC PEPGSSPPQR TPGHQNSVQP GAASPSNPCP ATRSNSQTLS DAPFTTCPEG PARDMQPTMK FVMDTSKYWF KPNITREQAI ELLRKEEPGA FVIRDSSSYR GSFGLALKVQ EVPASAQSRP GEDSNDLIRH FLIESSAKGV HLKGADEEPY FGSLSAFVCQ HSIMALALPC KLTIPQRELG GADGASDSTD SPASCQKKSA GCHTLYLSSV SVETLTGALA VQKAISTTFE RDILPTPTVV HFKVTEQGIT LTDVQRKVFF RRHYPLTTLR FCGMDPEQRK WQKYCKPSWI FGFVAKSQTE PQENVCHLFA EYDMVQPASQ VIGLVTALLQ DAERM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. May promote apoptosis, via its cleavage by caspase-3.
  • 基因功能参考文献：
    1. CTEN activated the expression of TGFB1, thereby prompting epithelial-mesenchymal transition in lung adenocarcinoma cancer cells. PMID: 29985912
    2. Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1. PMID: 29102927
    3. Cten-Snail signaling pathway contributes to cell motility in colorectal cancer (CRC), mediated by the stabilization of Snail protein. PMID: 28691764
    4. Conclude that in colorectal cancer, Cten is upregulated by EGFR and Kras but downregulated by STAT3. PMID: 26852686
    5. Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma PMID: 26035355
    6. Cten expression mediates invasion of human lung cancer cells and is upregulated by epidermal growth factor via STAT3. PMID: 25439778
    7. Findings indicate that induction of Cten protein expression is a relatively early event in melanoma progression, and that Cten has the potential to serve as a prognostic marker for primary melanoma patients. PMID: 24244691
    8. Up-regulated cten modulates cell migration induced by FGF2. PMID: 23625726
    9. Significant correlation between MET and TNS4 expression in human colon carcinoma and ovarian carcinoma suggests TNS4 plays a critical role in MET stability in cancer. PMID: 24814316
    10. CTEN regulates EGFR protein levels through a posttranslational mechanism. PMID: 23774213
    11. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. PMID: 23500447
    12. Show an oncogenic role for CTEN in pancreatic cancer through promotion of colony formation and cell motility. PMID: 22750970
    13. conclude that, in the colon and pancreas, Cten is a downstream target of Kras and may be a mechanism through which Kras regulates of cell motility PMID: 21698197
    14. Cten expression is of prognostic significance in colorectal carcinoma, and delineate a Cten-ILK pathway controlling cell motility and possibly promoting metastasis. PMID: 21339732
    15. CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma. PMID: 20390342
    16. Increased cten mRNA expression was correlated with tumor progression in lung cancers PMID: 12711115
    17. Cten/GAPDH mRNA expression was correlated with evidence of tumor progression in thymoma. PMID: 15001839
    18. These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity. PMID: 17190795
    19. Expression of CTEN correlates with high tumor grade and metastasis to lymph nodes, suggesting that CTEN may contribute to tumor invasiveness. PMID: 17765673
    20. TNS4 mRNA expression was significantly higher in gastric cancer. PMID: 18612693
    21. Cten is a novel nuclear partner of beta-catenin, and has an oncogenic activity in colon cancers. PMID: 19487278
    22. CTEN plays an important role in paclitaxel sensitivity, and CTEN expression level may be a prognostic predictive factor for prostate cancer patients. PMID: 19725034

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  • 亚细胞定位：
    Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Prostate and placenta. Down regulated in prostate cancer.
  • 数据库链接：

    HGNC: 24352

    OMIM: 608385

    KEGG: hsa:84951

    STRING: 9606.ENSP00000254051

    UniGene: Hs.438292