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  4. TOB1 (Ab-164) Antibody

TOB1 (Ab-164) Antibody

  • 货号：
    CSB-PA442764
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HT-29 cells, treated with serum (20%, 15mins), using TOB1 (Ab-164) antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using TOB1 (Ab-164) antiobdy.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TOB1 Polyclonal antibody
  • Uniprot No.：
    P50616
  • 基因名：
    TOB1
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized non-phosphopeptide derived from Human TOB1 around the phosphorylation site of serine 164 (A-V-S(p)-P-T).
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay.
  • 基因功能参考文献：
    1. MiR-590 targets Tob1 that is significantly decreased in patients with multiple sclerosis. PMID: 28947212
    2. The dual-luciferase reporter assay also confirmed that miR-25 harbored the A allele which caused an incapacitation of binding at the TOB1. In conclusion, rs41274221 in miR-25 was a subgroup which may protect the patients from further growth and metastasis of gastric cancer and might serve as a novel biomarker for the disease PMID: 26572149
    3. A novel role for TOB1 in mediating survival of estrogen-independent breast cancers. PMID: 26165839
    4. Reduced TOB1 expression in gastric adenocarcinoma is associated with the extent of differentiation and the TNM stage of gastric cancer. PMID: 25760308
    5. miR-25 promotes GC progression by directly downregulating TOB1 expression, and may be a noninvasive biomarker for the prognosis of GC patients. PMID: 25043310
    6. arsenite-induced oxidative stress inhibits deadenylation of mRNA primarily through downregulation of Tob and Pan3, both of which mediate the recruitment of deadenylases to mRNA PMID: 25446091
    7. Tob is a key factor in the regulation of c-myc gene expression, which is essential for cell growth. PMID: 23178487
    8. TOB1 demonstrated a radioprotective function in the immortalized normal human bronchial epithelial cell line. PMID: 23756562
    9. TOB1 modulates the radiosensitivity of lung cancer cells via the MAPK/ERK signaling pathway. PMID: 23589165
    10. Cdc7 phosphorylates and interacts with Tob to inhibit the Cul4-DDB1(Cdt2)-dependent Tob degradation. PMID: 23066029
    11. study demonstrates that the overexpression of Tob1 inhibits gastric cancer progression by activating Smad4- and inhibiting betacatenin-mediated signaling pathways PMID: 22710759
    12. TOB1 overexpression not only increased the expression of the phosphatase and tensin homolog (PTEN), an important tumor suppressor, but also regulated the downstream effectors in the PI3K/PTEN signaling pathway, including Akt, ERK1/2, etc. PMID: 22158108
    13. The antiproliferative and the mRNA deadenylation/decay-promoting effects of TOB1 and TOB2 proteins are linked. PMID: 22252318
    14. Silencing of HIC1 and TOB1 expression is a common occurrence in gastric cancer and may contribute to the development and progression of the disease. PMID: 21533545
    15. Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). PMID: 21577013
    16. Together, these results indicate that Tob mediates the recruitment of Caf1 to the target of CPEB3 and elicits deadenylation and decay of the mRNA. PMID: 21336257
    17. Tob interactions with Caf1 and a C-terminal domain of PABPC1 PMID: 20595394
    18. functions as lateral signal transmitter PMID: 11904957
    19. Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. the C-terminal regions are necessary and sufficient to control the stabilities of BTG1, BTG2, Tob, and Tob2 proteins. PMID: 12135500
    20. identified as a MAPK substrate PMID: 12151396
    21. Decreased expression or phosphorylation status of tob protein is associated with lung cancer PMID: 14643028
    22. N-terminal region of TOB is a functional nuclear export signal. PMID: 15051490
    23. Tob is involved in the translational suppression of IL-2 mRNA in anergic T cells through its interaction with iPABP. PMID: 15676026
    24. Tob1 is a novel target for degradation by the SCF-Skp2 ubiquitin ligase in a cell line. PMID: 16951159
    25. Reverse-transcription polymerase chain reaction confirmed increased expression of GADD45A, BTG2, PDE4B, and CEBPD and downregulation of TOB1 in skeletal muscle intradialysis. PMID: 16997058
    26. Subtractive hybridization identified Twisted gastrulation (Tsg) as one of the genes suppressed by Tob. PMID: 17164348
    27. Data show that TOB enhances mRNA deadenylation in vivo, and that interaction with PABPC1 is necessary for TOB's deadenylation-enhancing effect. PMID: 17785442
    28. antiproliferative region of human Tob (residues 1-138) and intact hCaf1 were co-expressed in Escherichia coli, purified and successfully cocrystallized PMID: 18084094
    29. Tob associates with the CCR4-NOT complex. PMID: 18377426
    30. positive correlation of TOB1 phosphorylation status with proliferation marker Ki67 suggests that elevated TOB1 phosphorylation might abrogate the antiproliferative effect of TOB1 in breast cancer PMID: 19491269
    31. Down-regulation of TOB is associated with breast cancer tumorigenesis. PMID: 19569230

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    BTG family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 11979

    OMIM: 605523

    KEGG: hsa:10140

    STRING: 9606.ENSP00000268957

    UniGene: Hs.703321