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TRIM36 Antibody

  • 货号：
    CSB-PA868285LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA868285LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA868285LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRIM36 Polyclonal antibody
  • Uniprot No.：
    Q9NQ86
  • 基因名：
    TRIM36
  • 别名：
    Acrosome RBCC protein antibody; E3 ubiquitin protein ligase TRIM36 antibody; E3 ubiquitin-protein ligase Trim36 antibody; Haprin antibody; RBCC728 antibody; RING finger protein 98 antibody; RNF98 antibody; TRI36_HUMAN antibody; TRIM 36 antibody; Trim36 antibody; Tripartite motif containing 36 antibody; Tripartite motif containing protein 36 antibody; Tripartite motif protein 36 antibody; Tripartite motif-containing protein 36 antibody; Zinc binding protein Rbcc728 antibody; Zinc-binding protein Rbcc728 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase TRIM36 protein (70-280AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TRIM36 Antibody (CSB-PA868285LA01HU)，的标记方式是Non-conjugated。对于TRIM36 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA868285LB01HU TRIM36 Antibody, HRP conjugated ELISA
    FITC CSB-PA868285LC01HU TRIM36 Antibody, FITC conjugated
    Biotin CSB-PA868285LD01HU TRIM36 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
  • 基因功能参考文献：
    1. aberrant hypermethylation of TRIM36 might be involved in the acquisition of malignant phenotype and could be served as a biomarker for risk assessment of PAHs exposure PMID: 28359976
    2. The siRNA knock down of TRIM36 in HeLa and LN229 cells also led to reduced cell proliferation and increased apoptosis. We suggest that microtubule disruption and disorganized spindles mediated by mutant TRIM36 affect neural cell proliferation during neural tube formation, leading to Anencephaly . PMID: 28087737
    3. TRIM36 is the causative gene for autosomal recessive anencephaly PMID: 28087737
    4. The overexpression of the TRIM36 in the vast majority of prostate cancer suggest that this gene might be involved in the prostate tumorigenesis. PMID: 15145053
    5. molecular cloning and characterization of a human haprin ortholog. PMID: 15955891
    6. TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H, potentially associated with chromosome segregation and its excess may cause chromosomal instability. PMID: 19232519

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  • 相关疾病：
    Anencephaly (ANPH)
  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart. Expressed in fetal tissues.
  • 数据库链接：

    HGNC: 16280

    OMIM: 206500

    KEGG: hsa:55521

    STRING: 9606.ENSP00000282369

    UniGene: Hs.519514