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  4. Recombinant Human E3 ubiquitin-protein ligase TRIM36 (TRIM36)

Recombinant Human E3 ubiquitin-protein ligase TRIM36 (TRIM36)

  • 货号：
    CSB-YP868285HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP868285HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP868285HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP868285HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP868285HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TRIM36
  • Uniprot No.：
  • 别名：
    Acrosome RBCC protein; E3 ubiquitin protein ligase TRIM36; E3 ubiquitin-protein ligase Trim36; Haprin; RBCC728; RING finger protein 98; RNF98; TRI36_HUMAN; TRIM 36; Trim36; Tripartite motif containing 36; Tripartite motif containing protein 36; Tripartite motif protein 36; Tripartite motif-containing protein 36; Zinc binding protein Rbcc728; Zinc-binding protein Rbcc728
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-728
  • 氨基酸序列
    MSESGEMSEF GYIMELIAKG KVTIKNIERE LICPACKELF THPLILPCQH SICHKCVKEL LLTLDDSFND VGSDNSNQSS PRLRLPSPSM DKIDRINRPG WKRNSLTPRT TVFPCPGCEH DVDLGERGIN GLFRNFTLET IVERYRQAAR AATAIMCDLC KPPPQESTKS CMDCSASYCN ECFKIHHPWG TIKAQHEYVG PTTNFRPKIL MCPEHETERI NMYCELCRRP VCHLCKLGGN HANHRVTTMS SAYKTLKEKL SKDIDYLIGK ESQVKSQISE LNLLMKETEC NGERAKEEAI THFEKLFEVL EERKSSVLKA IDSSKKLRLD KFQTQMEEYQ GLLENNGLVG YAQEVLKETD QSCFVQTAKQ LHLRIQKATE SLKSFRPAAQ TSFEDYVVNT SKQTELLGEL SFFSSGIDVP EINEEQSKVY NNALINWHHP EKDKADSYVL EYRKINRDDE MSWNEIEVCG TSKIIQDLEN SSTYAFRVRA YKGSICSPCS RELILHTPPA PVFSFLFDEK CGYNNEHLLL NLKRDRVESR AGFNLLLAAE RIQVGYYTSL DYIIGDTGIT KGKHFWAFRV EPYSYLVKVG VASSDKLQEW LRSPRDAVSP RYEQDSGHDS GSEDACFDSS QPFTLVTIGM QKFFIPKSPT SSNEPENRVL PMPTSIGIFL DCDKGKVDFY DMDQMKCLYE RQVDCSHTLY PAFALMGSGG IQLEEPITAK YLEYQEDM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
  • 基因功能参考文献：
    1. aberrant hypermethylation of TRIM36 might be involved in the acquisition of malignant phenotype and could be served as a biomarker for risk assessment of PAHs exposure PMID: 28359976
    2. The siRNA knock down of TRIM36 in HeLa and LN229 cells also led to reduced cell proliferation and increased apoptosis. We suggest that microtubule disruption and disorganized spindles mediated by mutant TRIM36 affect neural cell proliferation during neural tube formation, leading to Anencephaly . PMID: 28087737
    3. TRIM36 is the causative gene for autosomal recessive anencephaly PMID: 28087737
    4. The overexpression of the TRIM36 in the vast majority of prostate cancer suggest that this gene might be involved in the prostate tumorigenesis. PMID: 15145053
    5. molecular cloning and characterization of a human haprin ortholog. PMID: 15955891
    6. TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H, potentially associated with chromosome segregation and its excess may cause chromosomal instability. PMID: 19232519

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  • 相关疾病：
    Anencephaly (ANPH)
  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart. Expressed in fetal tissues.
  • 数据库链接：

    HGNC: 16280

    OMIM: 206500

    KEGG: hsa:55521

    STRING: 9606.ENSP00000282369

    UniGene: Hs.519514