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UGCG Antibody

  • 货号：
    CSB-PA156347
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA156347(UGCG Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q16739
  • 基因名：
    UGCG
  • 别名：
    UGCG; Ceramide glucosyltransferase; GLCT-1; Glucosylceramide synthase; GCS; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human UGCG
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer. Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures. Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction. They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway. They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope. The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids.
  • 基因功能参考文献：
    1. Studies show a connection between UDP-glucose ceramide glucosyltransferase (UGCG) and multidrug resistance protein 1 (MDR1) overexpression and multidrug resistance development [Review]. PMID: 29409484
    2. Results suggest that the changes of DNA methylation status of the glucosylceramide synthase (GCS) promoter correlates with multidrug resistance in breast cancer. PMID: 27191984
    3. Glucosylceramide synthase upregulation is associated with sorafenib resistance in hepatocellular carcinoma. PMID: 26811497
    4. GCS was upregulated in colorectal carcinoma tissues compared to control tissues. PMID: 25535133
    5. We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS) in the endometrium of endometriotic women. PMID: 24960545
    6. Our data demonstrates a correlation between the expression of the GCS protein and ER-positive/HER-2 negative breast cancer PMID: 24456584
    7. our work indicates that some UGCG polymorphisms are modifying factors in the severity of GD. PMID: 23913449
    8. GCS was upregulated in PTCs and might be an independent factor affecting prognosis. PMID: 24342307
    9. Glucosylceramide synthase mRNA were reduced by 62%. PMID: 24510559
    10. The results thus show that ARF6 regulates neuronal differentiation through an effect on glucosylceramide synthase and glucosylceramide levels. PMID: 23555901
    11. DOX could modulate the expression of GCS through the Sp1 site of GCS promoter in ERalpha-positive breast cancer cells PMID: 23133636
    12. Ceramide glycosylation catalyzed by glucosylceramide synthase is important for cancer stem cells in drug resistance and tumorigenesis. PMID: 22936806
    13. Data indicate that a high expression of glucosylceramide synthase (GCS) seemed to be an indicator of poor prognosis. PMID: 20843709
    14. The s conclude that hepatitis C virus proteins, especially NS5A and NS5B, have positive effects on the expression of human GlcT-1. PMID: 22270805
    15. GlcT-1 is up-regulated at the mRNA and protein levels during the course of U937 differentiation, resulting in increased amounts of GlcCer. PMID: 21558327
    16. Data show that nilotinib induces apoptosis through upregulating ceramide synthase genes and downregulating SK-1 in CML cells in addition to inhibition of BCR/ABL. PMID: 21756066
    17. GCS overexpression was highly associated with ER-positive and HER2-positive breast cancer with metastasis. PMID: 21617856
    18. Data show that GCS silencing increased the levels of phosphorylated p53 and p53-responsive genes. PMID: 21278235
    19. inhibition of the GCS gene affects the expression of MDR1 mRNA and P-gp function. PMID: 21380926
    20. GCSshRNA could efficiently suppress GCS and MDR1 expression in vitro and in vivo and these findings may be used as one of the methods to reverse multidrug resistance in breast cancer PMID: 19693666
    21. study demonstrates, for the first time, that GCS upregulates MDR1 expression modulating drug resistance of cancer. GSLs, in particular globo series GSLs mediate gene expression of MDR1 through cSrc and beta-catenin signaling pathway PMID: 20540746
    22. Positive correlation was detected between the expression of GCS and MDR1 mRNA in K562/A02 cells and MDR1 mRNA expression was down regulated after silencing the GCS gene expression. PMID: 20533270
    23. serve as negative regulator for ceramide PMID: 11915344
    24. Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. PMID: 12873973
    25. inhibition of glucosylceramide synthase led to increased CER galactosylation and protected U937 and HL-60 cells from DNR-induced apoptosis PMID: 14766899
    26. glucosylceramide synthase is not solely responsible for drug resistance in cancer cells PMID: 15263008
    27. p-gp confers resistance to ceramide-induced apoptosis, with modulation of the ceramide-glucosylceramide pathway GCS making a marked contribution to this resistance PMID: 15661399
    28. 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h. Transferase activity, transferring glycol groups PMID: 15747776
    29. the reticulon family member RTN-1C has been expressed and purified in Escherichia coli and its molecular structure has been analysed by fluorescence and Circular Dichroism spectroscopy PMID: 16500619
    30. it is suggested that a high level of GCS in leukemia is possible contributed to multidrug resistance of leukemia cells. PMID: 17709137
    31. Western analysis for glucosylceramide synthase showed a significant decrease in Alzheimer disease brain consistent with the hypothesis that enzyme dysfunction contributes to neuronal decay. PMID: 18155680
    32. High glucosylceramide synthase is associated with breast cancer. PMID: 18560890

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  • 亚细胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glycosyltransferase 2 family
  • 组织特异性：
    Found in all tissues examined.
  • 数据库链接：

    HGNC: 12524

    OMIM: 602874

    KEGG: hsa:7357

    STRING: 9606.ENSP00000363397

    UniGene: Hs.304249