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VWA5A Antibody

  • 货号：
    CSB-PA000991
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using BCSC-1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O00534
  • 基因名：
    VWA5A
  • 别名：
    VWA5A antibody; BCSC1 antibody; LOH11CR2A antibody; von Willebrand factor A domain-containing protein 5A antibody; Breast cancer suppressor candidate 1 antibody; BCSC-1 antibody; Loss of heterozygosity 11 chromosomal region 2 gene A protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human BCSC-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.
  • 基因功能参考文献：
    1. BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype. PMID: 22594792
    2. LOH11CR2A, PIG8 and CHEK1 are candidate tumor suppressor genes associated with breast carcinoma and have significant clinical as well as prognostic importance. PMID: 21803008
    3. BCSC-1 suppression might play roles in tumorigenesis of some nasopharyngeal carcinomas PMID: 19656157
  • 组织特异性：
    Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.
  • 数据库链接：

    HGNC: 6658

    OMIM: 602929

    KEGG: hsa:4013

    STRING: 9606.ENSP00000376504

    UniGene: Hs.152944