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ZBP1 Antibody

  • 货号：
    CSB-PA026311GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H171
  • 基因名：
  • 别名：
    C20orf183 antibody; DAI antibody; DLM 1 antibody; DLM1 antibody; DNA-dependent activator of interferon regulatory factors antibody; DNA-dependent activator of IRFs antibody; OTTHUMP00000031373 antibody; OTTHUMP00000174290 antibody; OTTHUMP00000237854 antibody; Tumor stroma and activated macrophage protein DLM 1 antibody; Tumor stroma and activated macrophage protein DLM-1 antibody; Z-DNA-binding protein 1 antibody; ZBP 1 antibody; Zbp1 antibody; ZBP1_HUMAN antibody; ZDBP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human ZBP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death. Once activated upon Z-RNA-binding, ZBP1 interacts with RIPK3, inducing the complementary pathways of apoptosis, necroptosis and pyroptosis. Acts as a key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members: ZBP1-dependent necroptosis involves RIPK3 stimulation, which phosphorylates and activates MLKL, triggering execution of programmed necrosis. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps. In some cell types, also able to restrict viral replication by promoting cell death-independent responses. In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate. Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes.; (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms hetero-amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit ZBP1-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion.
  • 基因功能参考文献：
    1. this paper reviews the history and emergence of ZBP1 as a pathogen sensor and a central regulator of cell death and inflammatory responses PMID: 29236673
    2. PUMA promotes the cytosolic release of mitochondrial DNA and activation of the DNA sensors DAI/Zbp1 and STING, leading to enhanced RIP3 and MLKL phosphorylation in a positive feedback loop. PMID: 29581256
    3. There is a correlation between the decrease in DAI-1 receptor expression and the severity of disease progression in preeclampsia. PMID: 29127557
    4. Our results show that HSV2 is detected by a plethora of PRRs including DAI protein which trigger cytokine secretion to protect the host. PMID: 24080302
    5. DAI could function as a DNA sensor and a regulator in DNA-induced macrophage M2b polarization and lupus nephritis. PMID: 23553627
    6. Collectively, these results demonstrate that DAI can suppress HSV-1 growth independent of DNA sensing through mechanisms involving suppression of viral genomes and regulation of ICP0. PMID: 23283962
    7. The data of this study suggest that RNA-binding proteins can be used as a tool to identify the post-transcriptional regulation of gene expression in the establishment and function of neural circuits involved in addiction behaviors. PMID: 22240322
    8. these data indicate that ZBP1 may function as an adapter to export the Ro/Y3 RNA complex from nuclei. PMID: 22114317
    9. Solution structure of the Zbeta domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B- and Z-DNAs. PMID: 21471454
    10. hZbeta(DAI) binds to Z-DNA via an active-di B-Z transition mechanism. PMID: 21296080
    11. These results suggest that activation of DAI might contribute to augment HIV-1 replication through DAI- NF-kappaB pathway. PMID: 20599623
    12. identify ZBP1 as being essential for IRF3 activation and interferon beta expression triggered by HCMV, as well as being sufficient to enhance HCMV-stimulated beta interferon transcription and secretion. PMID: 19846511
    13. molecular cloning and structure analysis PMID: 11842111
    14. Z-DNA binding activities of two Zalpha domains in the human ZBP1, hZalpha(ZBP1) and hZbeta(ZBP1)were characterized. PMID: 16448869
    15. In conclusion, intracellular bacteria and cytosolic poly(dA-dT) activate IFNbeta responses in different human cells without requiring human ZBP1. PMID: 18771559
    16. DAI binds to and colocalizes with endogenous adaptor receptor-interacting protein kinase (RIP)1 at characteristic cytoplasmic granules. PMID: 18941233
    17. binding 2 DAIs to 1 dsDNA brings about dimerization of DAI that might facilitate DNA-mediated innate immune activation. PMID: 19095800
    18. These data suggest that repression of ZBP1 by blocking beta-catenin binding at the ZBP1 promoter deregulates its associated mRNAs, leading to the phenotypic changes of breast cancers. PMID: 19461076

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  • 亚细胞定位：
    Cytoplasm. Nucleus.; [Isoform 7]: Cytoplasm. Nucleus.
  • 组织特异性：
    Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.
  • 数据库链接：

    HGNC: 16176

    OMIM: 606750

    KEGG: hsa:81030

    STRING: 9606.ENSP00000360215

    UniGene: Hs.302123