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ZNF350 Antibody

  • 货号：
    CSB-PA026694ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA026694ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA026694ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ZNF350 Polyclonal antibody
  • Uniprot No.：
    Q9GZX5
  • 基因名：
    ZNF350
  • 别名：
    KRAB zinc finger protein ZFQR antibody; ZBRK1 antibody; ZFQR antibody; Zinc finger and BRCA1 interacting protein with a KRAB domain 1 antibody; Zinc finger and BRCA1-interacting protein with a KRAB domain 1 antibody; Zinc finger protein 350 antibody; Zinc finger protein ZBRK1 antibody; ZN350_HUMAN antibody; ZNF350 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein 350 protein (233-532AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.
  • 基因功能参考文献：
    1. Results indicate ZNF350 as an important gene mammary oncogenesis. PMID: 29653063
    2. Results indicated that SNP rs2278414 at ZNF350 may in fl uence an individual's susceptibility to age-related cataract (ARC) by affecting the binding af fi nity of miR-21-3p and miR-150-5p and regulating expression levels of the mRNAs, resulting in different levels of cellular DNA breaks, thus contributing to ARC. PMID: 27586871
    3. villin directly interacts with a transcriptional corepressor and ligand of the Slug promoter, ZBRK1. PMID: 26658611
    4. ZBRK1 suppresses renal cancer progression perhaps by regulating VHL expression through formation of a complex with VHL and p300 in renal cancer PMID: 25749518
    5. MAGE proteins bind to KAP1, a gene repressor and ubiquitin E3 ligase which also binds KRAB domain containing zinc finger transcription factors (KZNFs), and MAGE expression may affect KZNF mediated gene regulation. PMID: 25107531
    6. The secondary structure of the ZBRK1-DNA complex is found to be significantly altered from the standard B-DNA conformation. PMID: 24924633
    7. results indicate that a loss of ZBRK1 contributes to the increased expression of KAP1, potentiating its role to enhance metastasis and invasion PMID: 23991171
    8. promoter assays in two breast cancer cell lines identified two haplotypes (H11 and H12) stimulating significantly the expression of ZNF350 transcript compared with the common haplotype H8 PMID: 23151675
    9. ZBRK1 negatively regulates the HIV-1 LTR PMID: 22975076
    10. high levels of gene activity in the genomic environment and the pre-deposition of repressive histone marks within a gene increase its susceptibility to KRAB/KAP1-mediated repression PMID: 21791101
    11. KRAB-containing zinc-finger transcriptional regulator, ZBRK1, an interaction partner of the SCA2 gene product ataxin-2. PMID: 20926453
    12. RB.E2F1 complex plays a critical role in ZBRK1 transcriptional repression, and loss of this repression may contribute to cellular sensitivity of DNA damage, ultimately leading to carcinogenesis. PMID: 20713352
    13. Data found that HMGA2, along with a dozen of other genes, was co-repressed by ZBRK1, BRCA1, and CtIP. PMID: 20007691
    14. KRAB/KAP1 recruitment induces long-range repression through the spread of heterochromatin. PMID: 20221260
    15. Our findings suggest that ZBRK1 acts to inhibit metastasis of cervical carcinoma, perhaps by modulating MMP9 expression. PMID: 19996286
    16. ZBRK1 mutation found in BRCA1 and BRCA2 mutation negative probands with breast or ovarian cancer. PMID: 12872252
    17. ZBRK1 is a novel target for DNA damage-induced degradation PMID: 14517299
    18. ZBRK1 zinc fingers have dual roles in sequence-specific DNA-binding and BRCA1-dependent transcriptional repression PMID: 14660588
    19. the CTRD is a novel protein interaction surface responsible for directing homotypic and heterotypic interactions necessary for ZBRK1-directed transcriptional repression PMID: 15496401
    20. interacts with BBLF2/3 to provide a tethering point on oriLyt for the EBV replication complex PMID: 15596820
    21. KRAB-induced transcriptional repression is robust and active over a variety of genomic contexts that include at least the wide range of sites targeted by lentiviral integration PMID: 16997916
    22. Genetic variants and haplotypes of the ZBRK1 gene is associated with breast and ovarian cancer PMID: 17764113
    23. KRAB/KAP1 regulation is fully functional within the context of episomal DNA PMID: 19279087
    24. BRCA1 and ZNF350 may jointly contribute to individuals' susceptibility of breast cancer in Chinese women. PMID: 19484476

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  • 亚细胞定位：
    Nucleus. Nucleus matrix. Note=Associated with the nuclear matrix.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 16656

    OMIM: 605422

    KEGG: hsa:59348

    STRING: 9606.ENSP00000243644

    UniGene: Hs.407694