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ZNF703 Antibody

  • 货号：
    CSB-PA026966GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H7S9
  • 基因名：
    ZNF703
  • 别名：
    FLJ14299 antibody; ZEPPO1 antibody; Zinc finger elbow-related proline domain protein 1 antibody; Zinc finger protein 703 antibody; ZN703_HUMAN antibody; ZNF503L antibody; znf703 antibody; ZPO1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human ZNF703
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
  • 基因功能参考文献：
    1. ZNF703 can potently facilitate tumor growth and metastasis in many respects throughout the progression of CCA, which may act as an oncogene in CCA and can be considered as a novel potential therapeutic target. PMID: 27764785
    2. ZNF703 activated the PI3K/AKT/GSK-3beta signalling pathway and its downstream effectors, thus regulating the cell cycle and epithelial-mesenchymal transition. PMID: 29176314
    3. Results show that ZNF703 is up-regulated in 63.4% of non-small cell lung cancer (NSCLC) tumor samples and it may contribute to tumor development by activating the Akt/mTOR pathway in NSCLC. PMID: 27650486
    4. In vitro function assays demonstrated that SPRY4-IT1 cause promotion of cell viability in ESCC cells. s further verified that SPRY4-IT1 could also activate the expression of ZNF703 in ESCC cells, which might contribute to the role of SPRY4-IT1 in ESCC cells. PMID: 27453415
    5. Results show that ZNF703 overexpression is associated with adverse prognosis in head and neck squamous cell carcinomas, which might be a novel biomarker for this type of neoplasm. PMID: 26063961
    6. ZNF703 was a target of SPRY4-IT1. PMID: 25742952
    7. Results show that ZNF703 expression is upregulated in colorectal cancer tissues (CRC) and is significantly correlated with tumor size, pathological grading, and serosal and lymph node metastasis suggesting that it may act as an oncogene in CRC. PMID: 25017610
    8. The results showed that ZNF703 acts as a gastric cancer oncogene PMID: 24481460
    9. High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer. PMID: 24156016
    10. Data indicate that ZNF703 overexpression in MCF-7 breast cancer cells activated the Akt/mTOR signaling pathway, downregulated ERalpha, and reduced the antitumor effect of tamoxifen. PMID: 23991038
    11. The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein. PMID: 22886885
    12. ZNF703 expression results in the activation of stem cell-related gene expression leading to an increase in cancer stem cells. PMID: 21328542
    13. These data strongly point to ZNF703 as a novel oncogene in Luminal B breast cancer. PMID: 21337521
    14. Data show that FGFR1 and DDHD2 at 8p12 cooperated functionally with MYC, whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53. PMID: 19330026

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  • 相关疾病：
    Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation.
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Elbow/Noc family
  • 组织特异性：
    Expressed in mammary epithelium.
  • 数据库链接：

    HGNC: 25883

    KEGG: hsa:80139

    STRING: 9606.ENSP00000332325

    UniGene: Hs.288042