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  4. Recombinant Human Zinc finger protein 703 (ZNF703)

Recombinant Human Zinc finger protein 703 (ZNF703)

  • 货号：
    CSB-YP026966HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP026966HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP026966HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP026966HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP026966HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZNF703
  • Uniprot No.：
  • 别名：
    FLJ14299; ZEPPO1; Zinc finger elbow-related proline domain protein 1; Zinc finger protein 703; ZN703_HUMAN; ZNF503L; znf703; ZPO1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-590
  • 氨基酸序列
    SDSPAGSNP RTPESSGSGS GGGGKRPAVP AAVSLLPPAD PLRQANRLPI RVLKMLSAHT GHLLHPEYLQ PLSSTPVSPI ELDAKKSPLA LLAQTCSQIG KPDPPPSSKL NSVAAAANGL GAEKDPGRSA PGAASAAAAL KQLGDSPAED KSSFKPYSKG SGGGDSRKDS GSSSVSSTSS SSSSSPGDKA GFRVPSAACP PFPPHGAPVS ASSSSSSPGG SRGGSPHHSD CKNGGGVGGG ELDKKDQEPK PSPEPAAVSR GGGGEPGAHG GAESGASGRK SEPPSALVGA GHVAPVSPYK PGHSVFPLPP SSIGYHGSIV GAYAGYPSQF VPGLDPSKSG LVGGQLSGGL GLPPGKPPSS SPLTGASPPS FLQGLCRDPY CLGGYHGASH LGGSSCSTCS AHDPAGPSLK AGGYPLVYPG HPLQPAALSS SAAQAALPGH PLYTYGFMLQ NEPLPHSCNW VAASGPCDKR FATSEELLSH LRTHTALPGA EKLLAAYPGA SGLGSAAAAA AAAASCHLHL PPPAAPGSPG SLSLRNPHTL GLSRYHPYGK SHLSTAGGLA VPSLPTAGPY YSPYALYGQR LASASALGYQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
  • 基因功能参考文献：
    1. ZNF703 can potently facilitate tumor growth and metastasis in many respects throughout the progression of CCA, which may act as an oncogene in CCA and can be considered as a novel potential therapeutic target. PMID: 27764785
    2. ZNF703 activated the PI3K/AKT/GSK-3beta signalling pathway and its downstream effectors, thus regulating the cell cycle and epithelial-mesenchymal transition. PMID: 29176314
    3. Results show that ZNF703 is up-regulated in 63.4% of non-small cell lung cancer (NSCLC) tumor samples and it may contribute to tumor development by activating the Akt/mTOR pathway in NSCLC. PMID: 27650486
    4. In vitro function assays demonstrated that SPRY4-IT1 cause promotion of cell viability in ESCC cells. s further verified that SPRY4-IT1 could also activate the expression of ZNF703 in ESCC cells, which might contribute to the role of SPRY4-IT1 in ESCC cells. PMID: 27453415
    5. Results show that ZNF703 overexpression is associated with adverse prognosis in head and neck squamous cell carcinomas, which might be a novel biomarker for this type of neoplasm. PMID: 26063961
    6. ZNF703 was a target of SPRY4-IT1. PMID: 25742952
    7. Results show that ZNF703 expression is upregulated in colorectal cancer tissues (CRC) and is significantly correlated with tumor size, pathological grading, and serosal and lymph node metastasis suggesting that it may act as an oncogene in CRC. PMID: 25017610
    8. The results showed that ZNF703 acts as a gastric cancer oncogene PMID: 24481460
    9. High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer. PMID: 24156016
    10. Data indicate that ZNF703 overexpression in MCF-7 breast cancer cells activated the Akt/mTOR signaling pathway, downregulated ERalpha, and reduced the antitumor effect of tamoxifen. PMID: 23991038
    11. The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein. PMID: 22886885
    12. ZNF703 expression results in the activation of stem cell-related gene expression leading to an increase in cancer stem cells. PMID: 21328542
    13. These data strongly point to ZNF703 as a novel oncogene in Luminal B breast cancer. PMID: 21337521
    14. Data show that FGFR1 and DDHD2 at 8p12 cooperated functionally with MYC, whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53. PMID: 19330026

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  • 相关疾病：
    Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation.
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Elbow/Noc family
  • 组织特异性：
    Expressed in mammary epithelium.
  • 数据库链接：

    HGNC: 25883

    KEGG: hsa:80139

    STRING: 9606.ENSP00000332325

    UniGene: Hs.288042