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beta-Spec Antibody

  • 中文名称：
    beta-Spec兔多克隆抗体
  • 货号：
    CSB-PA251598XA01DLU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes: beta-Spec Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 35.4 kDa
      Observed band size: 35.4 kDa
  • 其他：

产品详情

  • Uniprot No.：
    Q00963
  • 基因名：
    beta-Spec
  • 别名：
    Spectrin beta chain beta-Spec Spec-b CG5870
  • 反应种属：
    Drosophila melanogaster (Fruit fly)
  • 免疫原：
    Recombinant Drosophila melanogaster (Fruit fly) beta-Spec protein (1-271aa)
  • 免疫原种属：
    Drosophila melanogaster (Fruit fly)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Affinity-chromatography
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Interacts with calmodulin in a calcium-dependent manner.
  • 基因功能参考文献：
    1. The abnormal stress fiber-like actin structure on the basal side of follicle cells provides a likely link between the b-spectrin mutations and the loss of the Hippo signaling activity phenotype. PMID: 25589787
    2. Model in which alphabeta-spectrin directly couples lipid uptake at the plasma membrane to lipid droplet growth in the cytoplasm. In contrast, strong overexpression of beta-spectrin caused fat body atrophy and larval lethality. PMID: 24037266
    3. Data show that DAnk2-binding is critical for beta spectrin function in vivo. PMID: 20573981
    4. Spectrin may be an active partner in the stabilization of polarized membrane domains PMID: 14734656
    5. Presynaptic spectrin functions as an essential presynaptic scaffold that may link synaptic cell adhesion with the stabilization of the underlying microtubule cytoskeleton. PMID: 15916948
    6. Brush border spectrin is required for early endosome recycling. PMID: 16537648
    7. At the Drosophila neuromuscular junction postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged. PMID: 17088429
    8. beta-Spectrin is required in neurons for proper midline axon guidance in the embryonic CNS. PMID: 17121810

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
  • 蛋白家族：
    Spectrin family
  • 数据库链接：

    KEGG: dme:Dmel_CG5870

    STRING: 7227.FBpp0074228

    UniGene: Dm.7022