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brat Antibody

  • 中文名称：
    brat兔多克隆抗体
  • 货号：
    CSB-PA839760XA01DLU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes: brat Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 31 kDa
      Observed band size: 31 kDa
  • 其他：

产品详情

  • Uniprot No.：
    Q8MQJ9
  • 基因名：
    brat
  • 别名：
    Brain tumor protein brat CG10719
  • 反应种属：
    Drosophila melanogaster (Fruit fly)
  • 免疫原：
    Recombinant Drosophila melanogaster (Fruit fly) brat protein (294-487aa)
  • 免疫原种属：
    Drosophila melanogaster (Fruit fly)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Affinity-chromatography
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    A NHL-domain family protein that functions a translational repressor to inhibit cell proliferation. Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. During neuroblast division, segregates asymmetrically and inhibits self-renewal of one of the two daughter cells. Together with the asymmetrically segregating transcription factor prospero ensures that the daughter cell will stop growing, exit the cell cycle, and differentiate into neurons possibly by modulating the function of dm in ganglion mother cells (GMC). Restrics developmental potential of type II intermediary neuronal progenitor (INP) cells playing a role in proliferation and maturation of the neuroblasts.
  • 基因功能参考文献：
    1. Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor proteins has been described. PMID: 28318367
    2. Data suggest that brain tumor protein (Brat) promotes midline crossing through directing the localization or stability of Adenomatous polyposis coli-2 (Apc2) at the plus ends of microtubules in navigating commissural axons. PMID: 29617376
    3. results support a novel role for Brat/TRIM3 in maintaining stem cell equilibrium and suppressing tumor growth by regulating NICD nuclear transport PMID: 26893479
    4. BRAT is a prominent post-transcriptional regulator in the early embryo through mechanisms that are largely independent of PUM. PMID: 25962635
    5. that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction PMID: 25297111
    6. the Brat-dependent mechanism extinguishes the function of the self-renewal factor Klu in the presumptive intermediate progenitor cell by attenuating Arm activity, balancing stem cell maintenance and progenitor cell specification. PMID: 24257623
    7. These results together reveal an important and previously unidentified role for Brat in synaptic development and endocytosis mediated by suppression of BMP signaling. PMID: 23884941
    8. Cofactors Brain Tumor and eIF4E Homologous Protein are not obligatory for Pumilio and Nanos activity. PMID: 22064486
    9. Brain Tumor (Brat) was identified as a potent differentiation factor and target of Pum-Nos regulation. PMID: 21238926
    10. We show that Drosophila larval neuroblasts-stem cell-like precursors of the adult brain-regulate proliferation by segregating the growth inhibitor Brat and the transcription factor Prospero into only one daughter cell. PMID: 16564014
    11. Results suggest that the tumour suppressor brat negatively regulates cell proliferation during larval brain development in Drosophila, and that Prospero acts as a key downstream effector of brat in cell fate specification and proliferation control. PMID: 16774999

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cell cortex.
  • 组织特异性：
    Expressed during embryogenesis, mainly in nervous tissues. Expressed in the embryonic central and peripheral nervous systems including the embryonic brain. In third instar larva it is expressed in the larval central nervous system including the brain and
  • 数据库链接：

    KEGG: dme:Dmel_CG10719

    STRING: 7227.FBpp0293081

    UniGene: Dm.6426