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ULBP1 Recombinant Monoclonal Antibody

  • 货号：
    CSB-RA446786A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, Raji whole cell lysate, HEK293 whole cell lysate
      All lanes: ULBP1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 28 kDa
      Observed band size: 36-50 kDa
  • 其他：

产品详情

  • 产品描述：

    The ULBP1 recombinant monoclonal antibody was generated using the synthesized peptide derived from human ULBP1 protein as the immunogen. To obtain the DNA sequence of the SLC39A6 monoclonal antibody, the cDNA was sequenced and the gene was cloned into a plasmid vector. The plasmid vector containing the ULBP1 monoclonal antibody gene was then transfected into a host cell using an appropriate transfection method. The resulting ULBP1 recombinant monoclonal antibody underwent affinity-chromatography purification and was tested for specificity in an ELISA and WB applications. It can react with human ULBP1 protein.

    ULBP1 is a glycoprotein that functions as a ligand for the NKG2D receptor, a type of immune cell receptor that is primarily expressed on the surface of natural killer (NK) cells and a subset of T cells. ULBP1 is expressed on the surface of stressed or infected cells and plays an important role in the immune system's ability to recognize and eliminate infected or abnormal cells. When binding to NKG2D on the surface of NK cells, ULBP1 triggers a series of events that ultimately result in the activation of the NK cell and the destruction of the target cell.

  • Uniprot No.：
    Q9BZM6
  • 基因名：
  • 别名：
    UL16-binding protein 1 (ALCAN-beta) (NKG2D ligand 1) (N2DL-1) (NKG2DL1) (Retinoic acid early transcript 1I), ULBP1, N2DL1 RAET1I
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human ULBP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    13C8
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
  • 基因功能参考文献：
    1. we show that Simian Virus 40 (SV40)...evades NK cell attack through the down regulation of...ULBP1 PMID: 26992229
    2. ATF4 drives ULBP1 gene expression in cancer cell lines, while the RNA-binding protein RBM4 supports ULBP1 expression by suppressing a novel alternatively spliced isoform of ULBP1 mRNA. PMID: 26565589
    3. expression determines intrinsic acute myeloid leukemia susceptibility to allogeneic V[gamma]9V[delta]2 T cells PMID: 24911793
    4. recurrence-free survival of patients with ULBP1-negative hepatocellular carcinoma (HCC) was significantly shorter than that of patients with ULBP1-positive HCC PMID: 21756848
    5. recombinant ULBP1 fused to CD45 caused a reduction in cytotoxicity and degranulation by NK cells, implying a role for receptor ligand distribution in the activation of NK cell responses PMID: 21464092
    6. Data show that ULBP1, TFR2 and IFITM1 were associated with increased susceptibility to Vgamma9Vdelta2 T-cell cytotoxicity. PMID: 20220060
    7. These results identify Mult1 as a target for the MARCH family of E3 ligases PMID: 20870941
    8. As NKG2D ligand, ULBP1 are expressed on immature dendritic cells and plays an important role in the cytotoxic effect of NK cells against iDC. PMID: 18394338
    9. Data show that the protease NS3/4A of HCV down-regulates ULBP1 expression by inhibiting the transcription of ULBP1. PMID: 19500498
    10. ULBP1 binds to the NKG2D receptor and activates multiple signaling pathways in primary natural killer cells. PMID: 11777960
    11. The NKG2D ligand ULBP1 is up-regulated and readily detectable intracellularly in the endoplasmic reticulum of human cytomegalovirus-infected fibroblasts, where it colocalizes with viral protein UL16. PMID: 12847260
    12. ULBP1 is a human ligand of the NKG2D receptor PMID: 16901903
    13. The selective induction of ULBP1 expression by proteasome inhibitor drugs, along with variable NKG2D ligand expression by human tumor cells, indicates that NKG2D ligand genes are independently regulated. PMID: 19414815

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum.
  • 蛋白家族：
    MHC class I family
  • 组织特异性：
    Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
  • 数据库链接：

    HGNC: 14893

    OMIM: 605697

    KEGG: hsa:80329

    STRING: 9606.ENSP00000229708

    UniGene: Hs.653255