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  4. Recombinant Bovine Interleukin-1 receptor-associated kinase 4 (IRAK4)

Recombinant Bovine Interleukin-1 receptor-associated kinase 4 (IRAK4)

  • 中文名称：
    牛IRAK4重组蛋白
  • 货号：
    CSB-YP011812BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛IRAK4重组蛋白
  • 货号：
    CSB-EP011812BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛IRAK4重组蛋白
  • 货号：
    CSB-EP011812BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛IRAK4重组蛋白
  • 货号：
    CSB-BP011812BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛IRAK4重组蛋白
  • 货号：
    CSB-MP011812BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    IRAK4; Interleukin-1 receptor-associated kinase 4; IRAK-4; EC 2.7.11.1
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-461
  • 氨基酸序列
    MNKPITASTY VRCLSLGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ FHIRRFEALL QIGKSPTCEL LFDWGTTNCT VGDLVDILVQ NEFFAPASLL LPDAVPKNVN TLPSKVTVVA VQQKPKPLCG KDRTSVISDE NPEQNYVLPD SSSPENTSLE FSDTRFHSFS FFELKDVTNN FDERPISVGG NKMGEGGFGV VYKGYVNNRT VAVKKLAAMV DISTEELKQQ FDQEIKVMAK CQHENLVELL GFSSDGDDLC LVYVYMPNGS LLDRLSCLDG TPPLSWNMRC KIAQGAANGL SYLHENHHIH RDIKSANILL DEDFTAKISD FGLARASEKF AQTVMTSRIV GTTAYMAPEA LRGEITPKSD IYSFGVVLLE IITGLPAVDE HREPQLLLDI KEEIEDEEKT IEDYVDRKMN DIDSTSIETM YSVASQCLHE KKNKRPDIKK VQQLLEEMTG S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
  • 数据库链接：

    KEGG: bta:533692

    STRING: 9913.ENSBTAP00000028115

    UniGene: Bt.53276