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  4. Recombinant Bovine Three prime repair exonuclease 1 (TREX1)

Recombinant Bovine Three prime repair exonuclease 1 (TREX1)

  • 中文名称：
    牛TREX1重组蛋白
  • 货号：
    CSB-YP860617BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛TREX1重组蛋白
  • 货号：
    CSB-EP860617BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛TREX1重组蛋白
  • 货号：
    CSB-EP860617BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛TREX1重组蛋白
  • 货号：
    CSB-BP860617BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛TREX1重组蛋白
  • 货号：
    CSB-MP860617BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TREX1
  • Uniprot No.：
  • 别名：
    TREX1; Three-prime repair exonuclease 1; EC 3.1.11.2; 3'-5' exonuclease TREX1
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-315
  • 氨基酸序列
    MGSRALPPGP VQTLIFLDLE ATGLPFSQPK ITELCLLAVH RYALEGLSAP QGPSPTAPVP PRVLDKLSLC VAPGKVCSPA ASEITGLSTA VLAAHGRRAF DADLVNLIRT FLQRQPQPWC LVAHNGDRYD FPLLRAELAL LGLASALDDA FCVDSIAALK ALEPTGSSSE HGPRKSYSLG SVYTRLYGQA PPDSHTAEGD VLALLSVCQW RPRALLRWVD AHAKPFSTVK PMYVITTSTG TNPRPSAVTA TVPLARASDT GPNLRGDRSP KPAPSPKMCP GAPPGEGLLA PLGLLAFLTL AVAMLYGLSL AMPGQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族：
    Exonuclease superfamily, TREX family
  • 数据库链接：

    STRING: 9913.ENSBTAP00000011063

    UniGene: Bt.7472