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  4. Recombinant Candida albicans Mitogen-activated protein kinase HOG1 (HOG1)

Recombinant Candida albicans Mitogen-activated protein kinase HOG1 (HOG1)

  • 中文名称：
    白念珠菌HOG1重组蛋白
  • 货号：
    CSB-YP842094CZD
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    白念珠菌HOG1重组蛋白
  • 货号：
    CSB-EP842094CZD
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    白念珠菌HOG1重组蛋白
  • 货号：
    CSB-EP842094CZD-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    白念珠菌HOG1重组蛋白
  • 货号：
    CSB-BP842094CZD
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    白念珠菌HOG1重组蛋白
  • 货号：
    CSB-MP842094CZD
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOG1
  • Uniprot No.：
  • 别名：
    HOG1; CAALFM_C203330CA; CaO19.8514; CaO19.895; Mitogen-activated protein kinase HOG1; MAP kinase HOG1; EC 2.7.11.24
  • 种属：
    Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-377
  • 氨基酸序列
    MSADGEFTRT QIFGTVFEIT NRYTELNPVG MGAFGLVCSA VDRLTGQNVA VKKVMKPFST SVLAKRTYRE LKLLKHLKHE NLITLDDIFI SPLEDIYFVN ELQGTDLHRL LNSRPLEKQF IQYFTYQIMR GLKYIHSAGV IHRDLKPSNI LINENCDLKI CDFGLARLQD PQMTGYVSTR YYRAPEIMLT WQKYDTEVDL WSVGCILAEM IEGKPLFPGK DHVHQFSIIT ELLGSPPADV IDTICSENTL RFVQSLPHRD PIPFSERFAS CTHVEPEAID LLAKLLVFDP KKRISAVEGL THPYMEAYHD PTDEPVCESK FDWSFNDADL PVDTWRVMMY SEILDFHQTV GVANETEGSE QPDSQVEQNN LDSANGA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Regulates stress-induced production and accumulation of glycerol and D-arabitol. HOG1 is also involved in virulence, morphogenesis and oxidative stress response especially through its role in chlamydospore formation, an oxygen-dependent morphogenetic program.
  • 基因功能参考文献：
    1. functional analyses demonstrated that DTPA activates the mitogen-activated protein kinase Hog1, and that NIK1 mutations block Hog1 activation in response to both caspofungin and DTPA PMID: 27695031
    2. A novel role for the Hog1 stress-activated protein kinase pathway in regulating white-opaque switching and sexual behavior in C. albicans. PMID: 25344054
    3. The absence of a functional HOG pathway results in a failure to establish and to maintain stables fungal loads in the gut, indicating that the signaling through this route is a critical adaptive mechanism to colonize the mouse gastrointestinal tract. PMID: 24475243
    4. In Candida albicans, the MAP kinase Hog1p is part of the network regulating the response of the organism to iron availability. PMID: 23347662
    5. Crr1, a novel response regulator restricted to the Candida CTG clade, regulates the response of C. albicans cells to hydrogen peroxide in a Hog1-independent manner that requires the function of the conserved phospho-aspartate PMID: 22164221
    6. Hog1 mediates C. albicans virulence by conferring stress resistance rather than regulating morphogenesis PMID: 21994942

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Predominantly cytoplasmic in unstressed cells but rapidly concentrates within the nucleus in response to hyperosmotic conditions and phosphorylation.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, MAP kinase subfamily. HOG1 sub-subfamily
  • 数据库链接：

    KEGG: cal:CAALFM_C203330CA