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  4. Recombinant Danio rerio Achaete-scute homolog 1a (ascl1a)

Recombinant Danio rerio Achaete-scute homolog 1a (ascl1a)

  • 中文名称：
    Recombinant Danio rerio Achaete-scute homolog 1a(ascl1a),Yeast
  • 货号：
    CSB-YP852654DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Danio rerio Achaete-scute homolog 1a(ascl1a),Yeast
  • 货号：
    CSB-EP852654DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Danio rerio Achaete-scute homolog 1a(ascl1a),Yeast
  • 货号：
    CSB-EP852654DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Danio rerio Achaete-scute homolog 1a(ascl1a),Yeast
  • 货号：
    CSB-BP852654DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Danio rerio Achaete-scute homolog 1a(ascl1a),Yeast
  • 货号：
    CSB-MP852654DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ascl1a
  • Uniprot No.：
  • 别名：
    ascl1a; ash; ash1a; asha; piaAchaete-scute homolog 1a; Zash-1a; Pituitary-absent protein
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-196
  • 氨基酸序列
    MDITAKMEIS VNQQQFMPPA CFFASQSIQL SPTDSQCSNK SASKQAKRQR SSSPELLRCK RRLNFAGFGY SLPQQQPHAV ARRNERERNR VKLVNNGFAT LREHVPNGAA NKKMSKVETL RSAVEYIRAL QQLLDEHDAV SAAFQSGVLS PTISQNYSND MNSMAGSPVS SYSSDEGSYD PLSPEEQELL DFTNWF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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靶点详情

  • 功能：
    Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter. Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells.
  • 基因功能参考文献：
    1. dlx1a/2a act downstream of ascl1a but upstream of dlx5a/dlx6a and gad1b to activate GABAergic specification PMID: 23747543
    2. bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine PMID: 23352790
    3. Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility PMID: 23353550
    4. Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt signaling inhibitor, Dkk, and induced expression of the Wnt ligand, Wnt4a. PMID: 21911394
    5. The Ascl1a regulates Muller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. PMID: 20935637
    6. Expressed in the postsembryonic zebrafish brain PMID: 12638130
    7. ash1a and ngn1 function in parallel redundant pathways to regulate neurogenesis downstream of flh PMID: 12702659
    8. Ascl1a might act downstream of diencephalic fibroblast growth factor 3 (Fgf3) signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis PMID: 16481349
    9. Cellular correlates of proneural gene(ash1a) expression in the regenerating zebrafish retina. PMID: 17822581
    10. ascl1a is essential for retina regeneration: within 4 h after retinal injury, ascl1a is induced in Muller glia. PMID: 18234889

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    In the 24 hours embryo, expressed in the dorsal hindbrain in two bilaterally symmetrical lines of cells marking the boundary between the alar and basal plates, and ventrally in rhombomere 1 near the floor plate. Also expressed in embryonic adenohypophysis
  • 数据库链接：

    KEGG: dre:30466

    STRING: 7955.ENSDARP00000056004

    UniGene: Dr.314