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  4. Recombinant Danio rerio Survival motor neuron protein 1 (smn1)

Recombinant Danio rerio Survival motor neuron protein 1 (smn1)

  • 中文名称：
    斑马鱼smn1重组蛋白
  • 货号：
    CSB-YP895248DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斑马鱼smn1重组蛋白
  • 货号：
    CSB-EP895248DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斑马鱼smn1重组蛋白
  • 货号：
    CSB-EP895248DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斑马鱼smn1重组蛋白
  • 货号：
    CSB-BP895248DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斑马鱼smn1重组蛋白
  • 货号：
    CSB-MP895248DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    smn1; smn; Survival motor neuron protein 1
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-281
  • 氨基酸序列
    MANGAEDVVF CRGTGQSDDS DIWDDTALIK AYDKAVASFK NALKGEDGAT PQENDNPGKK RKNNKKNKSR KRCNAAPDKE WQVGDSCYAF WSEDGNLYTA TITSVDQEKG TCVVFYTDYG NEEEQNLSDL LTEPPDMDED ALKTANVKET ESSTEESDRS FTPQKSGHAK HKSKSNFPMG PPSWFPSFPP GPPPPPPHFK KMDGRRGEGP GPSFPGWPPM IPLGPPMIPP PPPMSPDFGE DDEALGSMLI SWYMSGYHTG YYMGLRQGRK EAAASKKSHR K
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites.
  • 基因功能参考文献：
    1. we established that the additional supply of Smn protein in motoneurons is necessary for proper axonogenesis in a cell-autonomous manner PMID: 27273160
    2. In motor neurons, smn1 interacts with the RNA binding protein, HuD and regulates motoneuron development and function. PMID: 29061699
    3. our finding that elevation of Pgk1 levels or activity, via injection of Pgk1 mRNA or treatment with terazosin respectively, robustly ameliorated MN pathology in smn morphant zebrafish provides an initial demonstration that these pathways are amenable to therapeutic intervention. PMID: 28426667
    4. Reduction of Gemin2, unlike reduction of SMN, in zebrafish embryos does not directly cause motor axon outgrowth defects. PMID: 18000835
    5. SMN deficiency affects splicing and abundance of nrxn2a. This may explain the pre-synaptic defects at neuromuscular endplates in SMA pathophysiology. PMID: 24218366
    6. SMN is needed early in development of motoneuron dendrites and axons to develop normally and that this is essential for proper connectivity and movement. PMID: 23459934
    7. These results show that survival motor neuron functions in motor axon development and suggest that these early developmental defects may lead to subsequent motoneuron loss. PMID: 12952942
    8. Survival motor neuron has a novel function in motor neurons independent of small nuclear ribonucleoprotein (snRNP) biosynthesis. PMID: 17065443
    9. Since Gemin2 and SMN both function in snRNP biogenesis yet only SMN knockdown causes motor axon defects, these data are consistent with an additional role for SMN that is snRNP independent. PMID: 18000835
    10. Smn mutants in zebrafish survive to larval stages and exhibit presynaptic neuromuscular junction defects. PMID: 19592581

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  • 亚细胞定位：
    Nucleus, gem. Nucleus, Cajal body. Cytoplasm. Cytoplasmic granule. Perikaryon. Cell projection, neuron projection. Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    SMN family
  • 数据库链接：

    KEGG: dre:30432

    STRING: 7955.ENSDARP00000017636

    UniGene: Dr.75206