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  4. Recombinant Danio rerio Transcription factor Sox-3 (sox3)

Recombinant Danio rerio Transcription factor Sox-3 (sox3)

  • 中文名称：
    斑马鱼sox3重组蛋白
  • 货号：
    CSB-YP738605DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斑马鱼sox3重组蛋白
  • 货号：
    CSB-EP738605DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斑马鱼sox3重组蛋白
  • 货号：
    CSB-EP738605DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斑马鱼sox3重组蛋白
  • 货号：
    CSB-BP738605DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斑马鱼sox3重组蛋白
  • 货号：
    CSB-MP738605DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    sox3
  • Uniprot No.：
  • 别名：
    sox3; zgc:110279; Transcription factor Sox-3
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-300
  • 氨基酸序列
    MYNMMETEIK SPIPQSNTGS VTGGKNNSAN DQDRVKRPMN AFMVWSRGQR RKMAQENPKM HNSEISKRLG ADWKLLTDAE KRPFIDEAKR LRAMHMKEHP DYKYRPRRKT KTLLKKDKYS LPGGLLAPGA NAVNNAVSVG QRMDYTHMNG WTNSAYSLMQ DQLAYPQHPS MNSPQIQQMH RYDMAGLQYP MMSTAQTYMN AASTYSSMSP AYTQQTSSAM GLGSMASVCK TEPSSPPPAI TSHSQRACLG DLRDMISMYL PPGGDSADHS SLQTSRLHSV HPHYQSAGTG VNGTLPLTHI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator.
  • 基因功能参考文献：
    1. these findings show that sox2 and sox3 are together required for proper otic induction, but the level of expression must be tightly regulated to avoid suppression of differentiation and maintenance of pluripotency. PMID: 29355522
    2. these data show that sox2 and sox3 exhibit intrinsic differences in promoting sensory vs. neural competence, but at high levels these factors can mimic each other to enhance both states. Regional cofactors like pax2a and fgf8 also modify sox2/3 functions. PMID: 29355523
    3. significant decreases in sox3 (up to 3-fold) expression following chilling. Significant increases in expression of sox3 (up to 33-fold) during warming of chilled zebrafish embyos. PMID: 21820425
    4. Knockdown of fgf24 or sox3 causes severe epibranchial deficiencies but has little effect on otic development PMID: 21215261
    5. Knockdown of the four B1 sox genes sox2/3/19a/19b resulted in severe developmental abnormalities. PMID: 20463883
    6. The pro-neural effects of Sox3 can compensate for inhibition of fibroblast growth factor (Fgf) signalling in inducing neural tissue but it is not sufficient to maintain neural fate, suggesting the presence of Sox3-independent roles of Fgf at later stages. PMID: 18572157

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: dre:30529

    STRING: 7955.ENSDARP00000070099

    UniGene: Dr.104569