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  4. Recombinant Dog COMM domain-containing protein 1 (COMMD1)

Recombinant Dog COMM domain-containing protein 1 (COMMD1)

  • 中文名称：
    Recombinant Dog COMM domain-containing protein 1(COMMD1),Yeast
  • 货号：
    CSB-YP837828DO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Dog COMM domain-containing protein 1(COMMD1),Yeast
  • 货号：
    CSB-EP837828DO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Dog COMM domain-containing protein 1(COMMD1),Yeast
  • 货号：
    CSB-EP837828DO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Dog COMM domain-containing protein 1(COMMD1),Yeast
  • 货号：
    CSB-BP837828DO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Dog COMM domain-containing protein 1(COMMD1),Yeast
  • 货号：
    CSB-MP837828DO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    COMMD1
  • Uniprot No.：
  • 别名：
    COMMD1; MURR1COMM domain-containing protein 1; Protein Murr1
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-188
  • 氨基酸序列
    MAAELEGSKA LGGLLSGLAQ EAFHGHHGIT EELLRSQLYP EVSLEEFRPF LAKMRGILKS IASADMDFNQ LEAFLTAQTK KQGGITSDQA AVISKFWKNH KTKIRESLMN QSRWDSGLRG LSWRVDGKSQ SRHSAQIHTP VAIMELEIGK SGQESEFLCL EFDEVKVSQL LKKLSEVEES ISTLMQPA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1. Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner.
  • 基因功能参考文献：
    1. Results show the prevalence and clinical relevance of exon 2 deletion of COMMD1 and could help establish a structured selective breeding program to prevent CT-BT in Korea PMID: 27727471
    2. The study has identified a significant disease association with a region on chromosome 37 containing identified single nucleotide polymorphism which are highly significantly associated with non-COMMD1 (del/del) Bedlington terrier copper toxicosis. This region contains the ABCA12 gene which bears a close functional relationship to ATP-ase 7B responsible for Wilson's disease in man. PMID: 27049130
    3. Commd1 loss of function mutation results in hypercholesterolemia. PMID: 26965651
    4. copper metabolism and oxidative stress related gene products were examined in COMMD1-deficient dogs. PMID: 25053573
    5. COMMD1-deficient dogs develop chronic liver disease and cirrhosis comparable to human chronic hepatitis, although at much higher pace. PMID: 22879914
    6. genomic deletion in MURR1 results in complete absence of MURR1 protein; results suggest a role for MURR1 in the regulation of vesicular copper sequestration during copper overload PMID: 14568250
    7. Prevalence of the exon 2 deletion of the COMMD1 gene in Australian Bedlington terriers as a possible marker of inherited copper toxicosis. PMID: 18305350

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  • 相关疾病：
    Defects in COMMD1 are the cause of copper toxicosis (CT) in Bedlington terriers, a genetic disease occurring with a high prevalence worldwide and is unique to this breed. In Bedlington terriers the biliary excretion of copper is impaired.
  • 亚细胞定位：
    Nucleus. Cytoplasm. Endosome membrane. Cytoplasmic vesicle. Early endosome. Recycling endosome.
  • 数据库链接：

    KEGG: cfa:403590

    STRING: 9615.ENSCAFP00000004595

    UniGene: Cfa.3453