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  4. Recombinant Drosophila melanogaster Complexin (cpx)

Recombinant Drosophila melanogaster Complexin (cpx)

  • 中文名称：
    Recombinant Drosophila melanogaster Complexin(cpx),Yeast
  • 货号：
    CSB-YP815533DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Complexin(cpx),Yeast
  • 货号：
    CSB-EP815533DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Complexin(cpx),Yeast
  • 货号：
    CSB-EP815533DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Complexin(cpx),Yeast
  • 货号：
    CSB-BP815533DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Complexin(cpx),Yeast
  • 货号：
    CSB-MP815533DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    cpx
  • Uniprot No.：
  • 别名：
    cpx; CG32490Complexin
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-139
  • 氨基酸序列
    MAAFIAKQMV GNQLSAVKGA VGGDGGDDGD DKEKAEEEER ERQEAIKEAE DRRKEKHRKM EEEREKMRQD IRDKYNIKKK EEIVEAAPQE EPNPLMRKKK TPEELAAEAE QEELDDFTKL KNQIETQVNE LKTQIEGKC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Positively regulates a late step in synaptic vesicle exocytosis.
  • 基因功能参考文献：
    1. Synapses lacking complexin have elevated spontaneous release that enables reliable tracking of the spontaneous recycling pool. PMID: 28077717
    2. SNARE fusion clamp Complexin undergoes activity-dependent phosphorylation that alters the basic properties of neurotransmission in Drosophila. PMID: 26590346
    3. the inhibitory and activating functions of Cpx are genetically separable, and can be mapped to distinct molecular mechanisms that differentially regulate the SNARE fusion machinery. PMID: 24982161
    4. These data indicate that the C-terminus of Drosophila complexin regulates both spontaneous and evoked neurotransmitter release through separate mechanisms PMID: 23159779
    5. These observations indicate CPX regulates both spontaneous and evoked fusion by modulating the timing and properties of synaptotagmin activation during the synaptic vesicle cycle. PMID: 23238737

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  • 亚细胞定位：
    Membrane; Lipid-anchor.
  • 蛋白家族：
    Complexin/synaphin family
  • 数据库链接：

    KEGG: dme:Dmel_CG32490

    STRING: 7227.FBpp0290013

    UniGene: Dm.20909