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  4. Recombinant Drosophila melanogaster Homeotic protein Sex combs reduced (Scr)

Recombinant Drosophila melanogaster Homeotic protein Sex combs reduced (Scr)

  • 中文名称：
    黑腹果蝇Scr重组蛋白
  • 货号：
    CSB-YP362586DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Scr重组蛋白
  • 货号：
    CSB-EP362586DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Scr重组蛋白
  • 货号：
    CSB-EP362586DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Scr重组蛋白
  • 货号：
    CSB-BP362586DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Scr重组蛋白
  • 货号：
    CSB-MP362586DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Scr
  • Uniprot No.：
  • 别名：
    Scr; CG1030; Homeotic protein Sex combs reduced
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-417
  • 氨基酸序列
    MDPDCFAMSS YQFVNSLASC YPQQMNPQQN HPGAGNSSAG GSGGGAGGSG GVVPSGGTNG GQGSAGAATP GANDYFPAAA AYTPNLYPNT PQAHYANQAA YGGQGNPDMV DYTQLQPQRL LLQQQQQQQQ QQHAHAAAAV AAQQQQQLAQ QQHPQQQQQQ QQANISCKYA NDPVTPGGSG GGGVSGSNNN NNSANSNNNN SQSLASPQDL STRDISPKLS PSSVVESVAR SLNKGVLGGS LAAAAAAAGL NNNHSGSGVS GGPGNVNVPM HSPGGGDSDS ESDSGNEAGS SQNSGNGKKN PPQIYPWMKR VHLGTSTVNA NGETKRQRTS YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLTERQIKI WFQNRRMKWK KEHKMASMNI VPYHMGPYGH PYHQFDIHPS QFAHLSA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required for proper development of the sex comb and to suppress improper prothoracic wing development.
  • 基因功能参考文献：
    1. Results from NMR spectroscopy show that spontaneous deamidation of Scr protein at residue Asn 321 reduces its affinity for target DNA. PMID: 26435141
    2. To test if Hox proteins directly use shape readout, study characterized Exd-Scr co-crystal structures. When minor groove-inserting residues of Scr were mutated to alanines, thus impairing its ability to use shape readout, the mutant proteins no longer preferred sequences containing these minor groove width minima. PMID: 25843630
    3. male-like pattern of SCR expression is independent of dsx function, and dsx F must be responsible for bringing about dimorphism in SCR expression, whereas dsx M function is required with Scr for the morphogenesis of sex comb. PMID: 23938378
    4. Dynamic changes in Sex comb reduced protein expression are responsible for the diversity seen in sex comb morphology. PMID: 23197370
    5. Results indicate that Scr functions as a homodimer to increase its transcriptional specificity and suggest that the formation of homeodomain (HD) homo- or heterodimers might underlie the functional distinction between very similar HD proteins in vivo. PMID: 22564794
    6. alteration in Scr expression expands or contracts the doublesex domain, and vice versa PMID: 21886483
    7. proteins bound at a pair of regulatory elements flanking the Scr promoter interact to stablize silencing PMID: 12072469
    8. identified new cis-regulatory DNAs in the approximately 50-kb Scr-Antp interval PMID: 12909726
    9. Scr gene expression is influenced by direct interaction between DSP1 and two Scr regulation elements PMID: 15610064
    10. Results describe the sex-specific regulation of a Sex combs reduced, a HOX gene contributing to the development and evolution of a secondary sexual trait. PMID: 17868668
    11. Differences in sex comb numbers reflect changes of Scr expression in tarsus primordia in Drosophila. PMID: 18184363

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family, Deformed subfamily
  • 组织特异性：
    In embryo, expressed in the labial and anterior prothoracic segments and the extreme posterior of the maxillary segment. In adult, expressed in the maxillary analgen of the eye and antennal imaginal disk and the labial and T1 leg imaginal disks.
  • 数据库链接：

    KEGG: dme:Dmel_CG1030

    STRING: 7227.FBpp0089393

    UniGene: Dm.2481