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  4. Recombinant Drosophila melanogaster Protein 60A (gbb)

Recombinant Drosophila melanogaster Protein 60A (gbb)

  • 中文名称：
    黑腹果蝇gbb重组蛋白
  • 货号：
    CSB-YP338804DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇gbb重组蛋白
  • 货号：
    CSB-EP338804DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇gbb重组蛋白
  • 货号：
    CSB-EP338804DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇gbb重组蛋白
  • 货号：
    CSB-BP338804DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇gbb重组蛋白
  • 货号：
    CSB-MP338804DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    gbb
  • Uniprot No.：
  • 别名：
    gbb; 60A; gbb-60A; TGFb-60A; CG5562Protein 60A; Protein glass bottom boat
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    336-455
  • 氨基酸序列
    SVSPN NVPLLEPMES TRSCQMQTLY IDFKDLGWHD WIIAPEGYGA FYCSGECNFP LNAHMNATNH AIVQTLVHLL EPKKVPKPCC APTRLGALPV LYHLNDENVN LKKYRNMIVK SCGCH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the growth of imaginal tissues and for patterning of the adult wing.
  • 基因功能参考文献：
    1. The results indicate that high-fat diet-induced Gbb signaling provokes insulin resistance by increasing tribbles expression. PMID: 27484164
    2. propose that Gbb/Cmpy corelease from presynaptic terminals defines a neuronal protransmission signal PMID: 25453556
    3. Glial Mav modulates muscle expression of Gbb. PMID: 22959350
    4. Studies indicate that glass bottom boat (Gbb) can be processed singly at a prodomain site or a main site to generate two active isoforms, Gbb15 and Gbb38. PMID: 22472647
    5. Data indicate that Gbb38, the large ligand form of the glass bottom boat (Gbb) exhibited greater signaling activity and a longer range than the shorter form Gbb15. PMID: 22472650
    6. Data demonstrate that crimpy (cmpy; CG13253) limits neuronal Gbb activity to permit appropriate regulation of neuromuscular junction growth. PMID: 21750037
    7. The dRich coordinates the Gbb-dependent modulation of synaptic growth and function with postsynaptic development. PMID: 21041451
    8. Gbb/BMP signaling is a new pathway critical for positive regulation of nutrient storage and energy homeostasis during development. PMID: 19914231
    9. The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. PMID: 12873382
    10. Gbb globally regulates NMJ function by controlling both the growth and transmitter release properties of the synapse. PMID: 14507784
    11. This present study demonstrates that the central synapses that coordinate motoneuron activation are also reliant on Gbb-dependent retrograde signaling. PMID: 15295025

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 组织特异性：
    Expressed in cells of the developing foregut and hindgut during germ band retraction and later embryonic stages. Expressed in the wing disk, mainly in the posterior compartment in the pteropleural and medial regions extending into the progenitors of the s
  • 数据库链接：

    KEGG: dme:Dmel_CG5562

    STRING: 7227.FBpp0072036

    UniGene: Dm.4758