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  4. Recombinant Drosophila melanogaster Protein apterous (ap)

Recombinant Drosophila melanogaster Protein apterous (ap)

  • 中文名称：
    Recombinant Drosophila melanogaster Protein apterous(ap),Yeast
  • 货号：
    CSB-YP329930DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Protein apterous(ap),Yeast
  • 货号：
    CSB-EP329930DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Protein apterous(ap),Yeast
  • 货号：
    CSB-EP329930DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Protein apterous(ap),Yeast
  • 货号：
    CSB-BP329930DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Protein apterous(ap),Yeast
  • 货号：
    CSB-MP329930DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ap
  • Uniprot No.：
  • 别名：
    ap; CG8376Protein apterous
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-469
  • 氨基酸序列
    MGVCTEERPV MHWQQSARFL GPGAREKSPT PPVAHQGSNQ CGSAAGANNN HPLFRACSSS SCPDICDHST KPFGNAYGTE SFRSYETADR ATFEDSAAKF SISRSRTDCT EVSDETTSGI SFKTEPFGPP SSPESTSDSK ITRNLDDCSG CGRQIQDRFY LSAVEKRWHA SCLQCYACRQ PLERESSCYS RDGNIYCKND YYSFFGTRRC SRCLASISSN ELVMRARNLV FHVNCFCCTV CHTPLTKGDQ YGIIDALIYC RTHYSIAREG DTASSSMSAT YPYSAQFGSP HNDSSSPHSD PSRSIVPTGI FVPASHVING LPQPARQKGR PRKRKPKDIE AFTANIDLNT EYVDFGRGSH LSSSSRTKRM RTSFKHHQLR TMKSYFAINH NPDAKDLKQL SQKTGLPKRV LQVWFQNARA KWRRMMMKQD GSGLLEKGEG ALDLDSISVH SPTSFILGGP NSTPPLNLD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the normal development of the wing and halter imaginal disks.
  • 基因功能参考文献：
    1. neurons expressing the transcription factor apterous, affect the modulation of female walking speed during courtship. PMID: 28401905
    2. These results raise the possibility that the daily oscillation of Ap expression in l-LNvs may contribute to the buffering of light-driven arousal in wild-type flies. PMID: 27853240
    3. Ap role in the neuronal cell fate specification PMID: 27148744
    4. Nplp1 neuropeptide neurons in the developing Drosophila nerve cord belong to two sub-classes; Tv1 and dAp neurons, generated by two distinct progenitors. Nplp1 neurons are specified by spatial cues PMID: 28414802
    5. our results indicate that ap is regulated in time and space by a three-step mechanism that generates a lineage compartment by integrating input from separatecis-regulatory modules for the initiation, refinement and maintenance of its expression PMID: 26468882
    6. in brain development, Ap is required for correct axon guidance and fasciculation of interneurons, and Ap-expressing cells may also be involved in the brain neuroendocrine system. PMID: 11862460
    7. Data show that normal cell proliferation is necessary for apterous expression at the level of the dorso-ventral boundary, which is mediated by vestigial, interacting in a dose-dependent way with apterous. PMID: 12485165
    8. necessary for expression of the Leucokinin neuropeptide in a pair of brain neurons located in the lateral horn region of the protocerebrum PMID: 12541314
    9. in the absence of vg, the IFM developmental program switches into the DFM developmental program.DFM development requires key regulatory genes such as cut (ct) and apterous (ap), whereas IFM development requires vestigial (vg). PMID: 12921740
    10. Apterous (Ap, a selector protein), and the Notch and Wingless (Wg) signaling pathways, can sequentially control wing development through direct regulation of Ser expression in instar stages PMID: 14701680
    11. Osa, a member of the Brahma chromatin-remodeling complex, as a positive modulator of Apterous activity in the Drosophila wing PMID: 15147766
    12. A new instance of transvection at the Drosophila apterous (ap) locus, is reported. PMID: 18202363
    13. The AP and NAT activities in ap56f females were significantly lower than in Canton S females in the norm PMID: 18672805

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in PNS and CNS.
  • 数据库链接：

    KEGG: dme:Dmel_CG8376

    STRING: 7227.FBpp0085394

    UniGene: Dm.4746