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  4. Recombinant Drosophila melanogaster Protein atonal (ato)

Recombinant Drosophila melanogaster Protein atonal (ato)

  • 中文名称：
    Recombinant Drosophila melanogaster Protein atonal(ato),Yeast
  • 货号：
    CSB-YP342195DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Protein atonal(ato),Yeast
  • 货号：
    CSB-EP342195DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Protein atonal(ato),Yeast
  • 货号：
    CSB-EP342195DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Protein atonal(ato),Yeast
  • 货号：
    CSB-BP342195DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Protein atonal(ato),Yeast
  • 货号：
    CSB-MP342195DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ato
  • Uniprot No.：
  • 别名：
    ato; CG7508Protein atonal
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-312
  • 氨基酸序列
    MSSSEIYRYY YKTSEDLQGF KTAAAEPYFN PMAAYNPGVT HYQFNGNTLA SSSNYLSANG FISFEQASSD GWISSSPASH RSESPEYVDL NTMYNGGCNN MAQNQQYGMI MEQSVVSTAP AIPVASPPAV EVMGSSNVGT CKTIPASAGP KPKRSYTKKN QPSTTATSTP TAAAESSASV NLYTEEFQNF DFDNSALFDD SVEDDEDLML FSGGEDFDGN DGSFDLADGE NQDAAAGGSG KKRRGKQITP VVKRKRRLAA NARERRRMQN LNQAFDRLRQ YLPCLGNDRQ LSKHETLQMA QTYISALGDL LR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection.
  • 基因功能参考文献：
    1. the regulation of ato expression in the Bolwig's organs primordium, was examined. PMID: 27693434
    2. three binding sites are essential for atonal induction in the posterior ocelli, but show considerable redundancy in the anterior ocellus. this difference parallels the distinct control of ato transcription in the posterior and anterior progenitors of the developing compound eyes. PMID: 27565023
    3. findings suggest a role for the non-bHLH portion of Ato proteins in modulating the function of the bHLH domain in eye neurogenesis and implicate specific aa residues of the bHLH in this process PMID: 21998072
    4. Ato and Sens selectively enhance abdominal SOP development in a Spitz-independent manner, suggesting additional genetic interactions between this proneural pathway and Abd-A. PMID: 20875816
    5. Regulation is disrupted by the rough eye allele of the amos locus. PMID: 11861566
    6. Sensory neurons of the Atonal lineage pioneer the formation of glomeruli within the adult Drosophila olfactory lobe. PMID: 11874920
    7. ato is required for the formation of both the auditory chordotonal sense organ and joint PMID: 12203727
    8. atonal fully rescues the phenotype of Math1 null mice PMID: 12372255
    9. Axonal position in the Drosophila CNS is determined by expression of the Robo3 receptor for the midline repellent Slit. Robo3 expression is dependent on expression of atonal protein. PMID: 12526771
    10. functional comparison of Drosophila atonal, mouse and Xenopus Ath5; findings suggest atonal family may occupy a position in a gene hierarchy where differences in gene regulation or function can be correlated with evolutionary diversity of eye development PMID: 12950631
    11. Regulates DE-cadherin transcriptionally. PMID: 16963016
    12. Kto/Skd act as essential coactivators for Ato expression during early retinal neurogenesis. PMID: 17585897
    13. Despite their high similarity, Ato antagonizes the olfactory promoting ability of Amos protein. PMID: 17709231
    14. Direct control of the proneural gene ato by retinal determination factors during eye development is reported. PMID: 18083159
    15. the regulation of Atonal expression in the developing Drosophila retina. PMID: 18832354
    16. Gain and loss of ato function suppresses and enhances tumor formation, respectively, in a Drosophila cancer. Paradigm PMID: 19243220

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Proneural clusters and sense organ precursors of the chordotonal organs, optic furrow of the eye-antennal disk and developing brain lobe.
  • 数据库链接：

    KEGG: dme:Dmel_CG7508

    STRING: 7227.FBpp0081318