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  4. Recombinant Drosophila melanogaster Ras-related protein Rab-3 (Rab3)

Recombinant Drosophila melanogaster Ras-related protein Rab-3 (Rab3)

  • 中文名称：
    黑腹果蝇Rab3重组蛋白
  • 货号：
    CSB-YP326528DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Rab3重组蛋白
  • 货号：
    CSB-EP326528DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Rab3重组蛋白
  • 货号：
    CSB-EP326528DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Rab3重组蛋白
  • 货号：
    CSB-BP326528DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Rab3重组蛋白
  • 货号：
    CSB-MP326528DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rab3
  • Uniprot No.：
  • 别名：
    Rab3; CG7576; Ras-related protein Rab-3
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-220
  • 氨基酸序列
    MASGGDPKWQ KDAADQNFDY MFKLLIIGNS SVGKTSFLFR YADDSFTSAF VSTVGIDFKV KTVFRHDKRV KLQIWDTAGQ ERYRTITTAY YRGAMGFILM YDVTNEDSFN SVQDWVTQIK TYSWDNAQVI LVGNKCDMED QRVISFERGR QLADQLGVEF FETSAKENVN VKAVFERLVD IICDKMSESL DADPTLVGGG QKGQRLTDQP QGTPNANCNC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
  • 基因功能参考文献：
    1. This study demonstrated that the Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction. PMID: 27022630
    2. Findings suggest that Rab3 controls the distribution of active zone components via a vesicle docking mechanism that is consistent with standard Rab protein function. PMID: 26317909
    3. Rab3 regulates basal synaptic strength and short-term plasticity at the level of release probability at individual sites. PMID: 21378971
    4. The data of this study defined roles for Rab3-GAP and Rab3 in synaptic homeostasis and uncover a mechanism, acting at a late stage of vesicle release, that opposes the progression of homeostatic plasticity. PMID: 21338884
    5. This study showed that the small GTPase Rab3 controls the protein composition and release probability of individual active zones at the Drosophila neuromuscular junction. PMID: 20005823

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 数据库链接：

    KEGG: dme:Dmel_CG7576

    STRING: 7227.FBpp0087352

    UniGene: Dm.2584