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  4. Recombinant Human Alpha N-terminal protein methyltransferase 1B (METTL11B)

Recombinant Human Alpha N-terminal protein methyltransferase 1B (METTL11B)

  • 中文名称：
    人METTL11B重组蛋白
  • 货号：
    CSB-YP722791HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人METTL11B重组蛋白
  • 货号：
    CSB-EP722791HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人METTL11B重组蛋白
  • 货号：
    CSB-BP722791HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人METTL11B重组蛋白
  • 货号：
    CSB-MP722791HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    METTL11B
  • Uniprot No.：
  • 别名：
    METTL11B; C1orf184; NRMT2; Alpha N-terminal protein methyltransferase 1B; EC 2.1.1.299; Methyltransferase-like protein 11B; X-Pro-Lys N-terminal protein methyltransferase 1B; NTM1B
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-283
  • 氨基酸序列
    MAHRGAHFAF RSRWQKTDDE LCRHSMSFIL HKAIRNDFFQ SYLYLLEKIP LVKLYALTSQ VINGEMQFYA RAKLFYQEVP ATEEGMMGNF IELSSPDIQA SQKFLRKFVG GPGRAGTDCA LDCGSGIGRV SKHVLLPVFN SVELVDMMES FLLEAQNYLQ VKGDKVESYH CYSLQEFTPP FRRYDVIWIQ WVSGHLTDKD LLAFLSRCRD GLKENGIIIL KDNVAREGCI LDLSDSSVTR DMDILRSLIR KSGLVVLGQE KQDGFPEQCI PVWMFALHSD RHS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro). May activate NTMT1 by priming its substrates for trimethylation.
  • 基因功能参考文献：
    1. Concurrent expression of NRMT1 and NRMT2 accelerates the production of trimethylation, and we propose that NRMT2 activates NRMT1 by priming its substrates for trimethylation. PMID: 24090352
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Methyltransferase superfamily, NTM1 family
  • 数据库链接：

    HGNC: 31932

    KEGG: hsa:149281

    STRING: 9606.ENSP00000408058

    UniGene: Hs.553612