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  4. Recombinant Human BRCA1-A complex subunit Abraxas (FAM175A)

Recombinant Human BRCA1-A complex subunit Abraxas (FAM175A)

  • 中文名称：
    Recombinant Human BRCA1-A complex subunit Abraxas(FAM175A),Yeast
  • 货号：
    CSB-YP747632HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human BRCA1-A complex subunit Abraxas(FAM175A),Yeast
  • 货号：
    CSB-EP747632HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human BRCA1-A complex subunit Abraxas(FAM175A),Yeast
  • 货号：
    CSB-EP747632HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human BRCA1-A complex subunit Abraxas(FAM175A),Yeast
  • 货号：
    CSB-BP747632HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human BRCA1-A complex subunit Abraxas(FAM175A),Yeast
  • 货号：
    CSB-MP747632HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ABRAXAS1
  • Uniprot No.：
  • 别名：
    3830405G04Rik; 5630400M01Rik; ABRA1; ABRAXAS; Abraxas protein; AI506069; AL024423; AV118690; BRCA1-A complex subunit Abraxas; coiled coil domain containing 98; Coiled-coil domain-containing protein 98; F175A_HUMAN; FAM175A; Family with sequence similarity 175 member A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-409
  • 氨基酸序列
    MEGESTSAVL SGFVLGALAF QHLNTDSDTE GFLLGEVKGE AKNSITDSQM DDVEVVYTID IQKYIPCYQL FSFYNSSGEV NEQALKKILS NVKKNVVGWY KFRRHSDQIM TFRERLLHKN LQEHFSNQDL VFLLLTPSII TESCSTHRLE HSLYKPQKGL FHRVPLVVAN LGMSEQLGYK TVSGSCMSTG FSRAVQTHSS KFFEEDGSLK EVHKINEMYA SLQEELKSIC KKVEDSEQAV DKLVKDVNRL KREIEKRRGA QIQAAREKNI QKDPQENIFL CQALRTFFPN SEFLHSCVMS LKNRHVSKSS CNYNHHLDVV DNLTLMVEHT DIPEASPAST PQIIKHKALD LDDRWQFKRS RLLDTQDKRS KADTGSSNQD KASKMSSPET DEEIEKMKGF GEYSRSPTF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
  • 基因功能参考文献：
    1. Our data also suggest how ataxia telangiectasia mutated (ATM)-dependent BRCA1 dimerization may stabilize self-association of the entire BRCA1-A complex. PMID: 28009280
    2. Results identified 16 novel rare variants in FAM175A but no significant difference in allele frequencies between cases and controls was observed which suggest no evidence that rare variants in ABRAXAS are associated with increased breast cancer risk in the population studied. PMID: 27270457
    3. Demonstrate a mechanism involving IR-induced phosphorylation and dimerization of the BRCT/Abraxas complex for regulating Abraxas-mediated recruitment of BRCA1 in response to IR. PMID: 26778126
    4. The recurrent Abraxas c.1082G>A mutation connects to breast cancer predisposition. PMID: 22357538
    5. low expression correlates with better response to chemotherapy and longer survival in patients with advanced non small-cell lung cancer PMID: 21529986
    6. CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage. PMID: 17643121
    7. CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response. PMID: 17643122
    8. Mutational analysis in 168 multiple-case breast/ovarian cancer families, negative for mutations in BRCA1 or BRCA2, suggests that CCDC98 does not play an important role as a high penetrance breast cancer susceptibility gene. PMID: 18270812
    9. examined RAP80 and Abraxas expression and their effect on treatment outcome in non-small-cell lung cancer PMID: 19415121

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  • 相关疾病：
    Breast cancer (BC)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    FAM175 family, Abraxas subfamily
  • 数据库链接：

    HGNC: 25829

    OMIM: 114480

    KEGG: hsa:84142

    STRING: 9606.ENSP00000369857

    UniGene: Hs.334772