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  4. Recombinant Human Centrosomal protein kizuna (PLK1S1)

Recombinant Human Centrosomal protein kizuna (PLK1S1)

  • 货号：
    CSB-YP644808HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP644808HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP644808HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP644808HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP644808HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KIZ
  • Uniprot No.：
  • 别名：
    Centrosomal protein kizuna; DKFZP586H021; HT013 ; Kiz; KIZ_HUMAN; KIZUNA; MGC102941; MGC141930; NCRNA00153 ; Plk1s1; Polo-like kinase 1 substrate 1; Uncharacterized protein C20orf19
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-673
  • 氨基酸序列
    MSRTLASAVP LSSPDYYERL GQLQHGLRDS EKKRLDLEKK LYEYNQSDTC RVKLKYVKLK NYLKEICESE KKAHTRNQEY LKRFERVQAH VVHFTTNTEK LQKLKLEYET QIKKMLCSKD SLGLKEELTD EDREKVAVHE GINSGTAMSR GLYQPATIFM GRQMSAILSM RDFSTEHKSP QPTKNFSIPD PHSHRQTAQS SNVTDSCVVQ TSNDTQCLNK SDNIDGKASL QIGEKMPVTA SVLSEEEQTH CLEIGSNTRH GKSNLSEGKK SAELNSPLRE RLSPENRTTD LKCDSSSGSE GEILTREHIE VEEKRASPPV SPIPVSEYCE SENKWSQEKH SPWEGVSDHL AHREPKSQKP FRKMQEEEEE SWSTSSDLTI SISEDDLILE SPEPQPNPGG KMEGEDGIEA LKLIHAEQER VALSTEKNCI LQTLSSPDSE KESSTNAPTR EPGQTPDSDV PRAQVGQHVA TLKEHDNSVK EEATALLRKA LTEECGRRSA IHSSESSCSL PSILNDNSGI KEAKPAVWLN SVPTREQEVS SGCGDKSKKE NVAADIPITE TEAYQLLKKA TLQDNTNQTE NRFQKTDASV SHLSGLNIGS GAFETKTANK IASEASFSSS EGSPLSRHEN KKKPVINLKS NALWDESDDS NSEIEAALRP RNHNTDDSDD FYD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
  • 基因功能参考文献：
    1. Kiz phosphorylation depends on a balance between CDC25B and Plk1 activities. PMID: 25558830
    2. Immunohistology revealed KIZ localization at the basal body of the cilia in human fibroblasts, thus shedding light on another ciliary protein implicated in autosomal-recessive RCD PMID: 24680887
  • 相关疾病：
    Retinitis pigmentosa 69 (RP69)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    Kizuna family
  • 数据库链接：

    HGNC: 15865

    OMIM: 615757

    KEGG: hsa:55857

    UniGene: Hs.187635