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  4. Recombinant Human D-tyrosyl-tRNA (Tyr) deacylase 1 (DTD1)

Recombinant Human D-tyrosyl-tRNA (Tyr) deacylase 1 (DTD1)

  • 中文名称：
    人DTD1重组蛋白
  • 货号：
    CSB-YP819477HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DTD1重组蛋白
  • 货号：
    CSB-EP819477HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DTD1重组蛋白
  • 货号：
    CSB-EP819477HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DTD1重组蛋白
  • 货号：
    CSB-BP819477HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DTD1重组蛋白
  • 货号：
    CSB-MP819477HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DTD1
  • Uniprot No.：
  • 别名：
    bA379J5.3; bA555E18.1; C20orf88; D tyrosyl tRNA deacylase 1 homolog; D-tyrosyl-tRNA(Tyr) deacylase 1; DNA unwinding element binding protein; DTD1; DTD1_HUMAN; DUE B; DUEB; HARS2; Histidyl tRNA synthetase 2; Histidyl-tRNA synthase-related; MGC119131; MGC41905; pqn 68
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-209
  • 氨基酸序列
    MKAVVQRVTR ASVTVGGEQI SAIGRGICVL LGISLEDTQK ELEHMVRKIL NLRVFEDESG KHWSKSVMDK QYEILCVSQF TLQCVLKGNK PDFHLAMPTE QAEGFYNSFL EQLRKTYRPE LIKDGKFGAY MQVHIQNDGP VTIELESPAP GTATSDPKQL SKLEKQQQRK EKTRAKGPSE SSKERNTPRK EDRSASSGAE GDVSSEREP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes.; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
  • 基因功能参考文献：
    1. The state of DUE-B phosphorylation is maintained by the equilibrium between Cdc7-dependent phosphorylation and PP2A-dependent dephosphorylation. PMID: 25258324
    2. LDI-PCR revealed a fusion between DTD1 exon 4 and PDGFRB exon 12 in the cases with t(5;14)(q33;q32) and t(5;20)(q33;p11). PMID: 24772479
    3. DTD1 variants do not affect the abnormalities of the upper airways in aspirin-intolerant asthma patients PMID: 21479357
    4. The coordinated binding of DUE-B and Cdc45 to origins and the physical interactions of DUE-B, Cdc45, and TopBP1 suggest that complexes of these proteins are necessary for replication initiation. PMID: 20065034
    5. cloning and identification of novel cDNA which may be associated with FKBP25 PMID: 12392168
    6. DUE-B, a c-myc DNA-unwinding element-binding protein, plays an important role in replication in vivo. PMID: 15653697

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements (PubMed:20065034).
  • 蛋白家族：
    DTD family
  • 组织特异性：
    Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain.
  • 数据库链接：

    HGNC: 16219

    OMIM: 610996

    KEGG: hsa:92675

    STRING: 9606.ENSP00000366672

    UniGene: Hs.659442