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  4. Recombinant Human Deoxyribonuclease-1-like 2 (DNASE1L2)

Recombinant Human Deoxyribonuclease-1-like 2 (DNASE1L2)

  • 中文名称：
    人DNASE1L2重组蛋白
  • 货号：
    CSB-YP849794HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DNASE1L2重组蛋白
  • 货号：
    CSB-EP849794HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DNASE1L2重组蛋白
  • 货号：
    CSB-BP849794HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DNASE1L2重组蛋白
  • 货号：
    CSB-MP849794HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DNASE1L2
  • Uniprot No.：
  • 别名：
    DNASE1L2; DHP1; DNAS1L2Deoxyribonuclease-1-like 2; EC 3.1.21.-; DNase I homolog protein DHP1; Deoxyribonuclease I-like 2; DNase I-like 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-299
  • 氨基酸序列
    ALRIGAFNIQ SFGDSKVSDP ACGSIIAKIL AGYDLALVQE VRDPDLSAVS ALMEQINSVS EHEYSFVSSQ PLGRDQYKEM YLFVYRKDAV SVVDTYLYPD PEDVFSREPF VVKFSAPGTG ERAPPLPSRR ALTPPPLPAA AQNLVLIPLH AAPHQAVAEI DALYDVYLDV IDKWGTDDML FLGDFNADCS YVRAQDWAAI RLRSSEVFKW LIPDSADTTV GNSDCAYDRI VACGARLRRS LKPQSATVHD FQEEFGLDQT QALAISDHFP VEVTLKFHR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.
  • 基因功能参考文献：
    1. Study surveyed the non-synonymous SNPs of DNASE1L2: 19 SNPs originating from frameshift/nonsense mutations found in DNASE1L2 resulted in loss of function of the enzyme. Thus, the present findings suggest that each of the minor alleles for these SNPs may serve as one of genetic risk factors for parakeratotic skin diseases such as psoriasis, even though they lack a worldwide genetic distribution. PMID: 28394916
    2. DNASE1L2 is generally well conserved with regard to the non-synonymous single nucleotide polymorphisms, thereby avoiding any marked reduction of the enzyme activity in human populations. PMID: 25576224
    3. Genotyping of 17 SNPs in the human deoxyribonuclease I-like 2 gene was performed using the PCR-RFLP method in three ethnic groups including 14 different populations. PMID: 23161465
    4. DNAS1L2 is activated via the NF-kappaB pathway, and an NF-kappaB binding site located within the 5' flanking region is identified as the cis-responsive element PMID: 15203207
    5. DNase1L2 plays an essential role in DNA degradation during terminal differentiation of epidermal KC. PMID: 16902420
    6. Terminal differentiation of nail matrix keratinocytes involves up-regulation of DNas1L2 but is independent of caspase 14. PMID: 17490414

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  • 亚细胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    DNase I family
  • 组织特异性：
    Preferentially expressed in the skin and up-regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum.
  • 数据库链接：

    HGNC: 2958

    OMIM: 602622

    KEGG: hsa:1775

    STRING: 9606.ENSP00000316938

    UniGene: Hs.103503