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  4. Recombinant Human ELMO domain-containing protein 1 (ELMOD1)

Recombinant Human ELMO domain-containing protein 1 (ELMOD1)

  • 中文名称：
    人ELMOD1重组蛋白
  • 货号：
    CSB-YP839788HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ELMOD1重组蛋白
  • 货号：
    CSB-EP839788HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ELMOD1重组蛋白
  • 货号：
    CSB-EP839788HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ELMOD1重组蛋白
  • 货号：
    CSB-BP839788HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ELMOD1重组蛋白
  • 货号：
    CSB-MP839788HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ELMOD1
  • Uniprot No.：
  • 别名：
    DKFZp547C176; ELMD1_HUMAN; ELMO domain containing 1; ELMO domain-containing protein 1; ELMO/CED 12 domain containing 1; Elmod1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-334
  • 氨基酸序列
    MKHFLRMLIQ VCLYFYCKFL WRCLKFVMRK LTGRCELQRI CYNTKPGASR TMKIETSLRD SKSKLLQTSV SVHPDAIEKT IEDIMELKKI NPDVNPQLGI SLQACLLQIV GYRNLIADVE KLRREAYDSD NPQHEEMLLK LWKFLKPNTP LESRISKQWC EIGFQGDDPK TDFRGMGLLG LYNLQYFAER DATAAQQVLS DSLHPKCRDI TKEEISKFSK AEWEKKRMDK AIGYSFAIVG INITDLAYNL LVSGALKTHF YNIAPEAPTL SHFQQTFCYL MHEFHKFWIE EDPMDIMEFN RVREKFRKRI IKQLQNPDMA LCPHFAASEG LINM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.
  • 基因功能参考文献：
    1. Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1-Dock180 and intersectin 1/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 = ELMO domain-containing protein 1; Dock180 = dedicator of cytokinesis protein 1 180 kDa) PMID: 28600358
    2. The non-opioid sigma-1 receptor (S1R) was identified as a novel effector of GAP activity of ELMOD1-3 proteins as its direct binding to either ELMOD1 or ELMOD2 resulted in loss of GAP activity. PMID: 24616099
  • 数据库链接：

    HGNC: 25334

    OMIM: 615456

    KEGG: hsa:55531

    STRING: 9606.ENSP00000265840

    UniGene: Hs.495779